Diastereoselective three-component Mannich reaction catalyzed by prolinated MWCNTs

Abstract

Asymmetric Mannich and Mannich-type reactions are important carbon-carbon bond-<br><br>-amino carbonyl derivatives.[1] -lactam and - -amino acid derivatives, peroxy acetylenic<br><br>alcohols/ethers, and medicinally important materials. Several strategies[2,3] are<br><br>-amino carbonyl compounds, including organocatalysis transition-metal catalysis, Bronsted and Lewis acid catalysis, phasetransfer<br><br>catalysis, biocatalysis and ionic-liquid catalysis.<br><br>Herein we report a highly anti-diastereoselective three-component Mannich reaction<br><br>of aromatic amines and aldehydes with cyclohexanone in water as solvent and efficient<br><br>nano organocatalyst. Reusability, easy workup, inexpensive, ready availability, short<br><br>reaction time and its high diastereoselctivity 70-100% makes this catalyst an attractive<br><br>alternative to the existing catalyst -amino carbonyls.