Diastereoselective three-component Mannich reaction catalyzed by prolinated MWCNTs
Year
: 2018
Abstract: Asymmetric Mannich and Mannich-type reactions are important carbon-carbon bond-
-amino carbonyl derivatives.[1] -lactam and - -amino acid derivatives, peroxy acetylenic
alcohols/ethers, and medicinally important materials. Several strategies[2,3] are
-amino carbonyl compounds, including organocatalysis transition-metal catalysis, Bronsted and Lewis acid catalysis, phasetransfer
catalysis, biocatalysis and ionic-liquid catalysis.
Herein we report a highly anti-diastereoselective three-component Mannich reaction
of aromatic amines and aldehydes with cyclohexanone in water as solvent and efficient
nano organocatalyst. Reusability, easy workup, inexpensive, ready availability, short
reaction time and its high diastereoselctivity 70-100% makes this catalyst an attractive
alternative to the existing catalyst -amino carbonyls.
-amino carbonyl derivatives.[1] -lactam and - -amino acid derivatives, peroxy acetylenic
alcohols/ethers, and medicinally important materials. Several strategies[2,3] are
-amino carbonyl compounds, including organocatalysis transition-metal catalysis, Bronsted and Lewis acid catalysis, phasetransfer
catalysis, biocatalysis and ionic-liquid catalysis.
Herein we report a highly anti-diastereoselective three-component Mannich reaction
of aromatic amines and aldehydes with cyclohexanone in water as solvent and efficient
nano organocatalyst. Reusability, easy workup, inexpensive, ready availability, short
reaction time and its high diastereoselctivity 70-100% makes this catalyst an attractive
alternative to the existing catalyst -amino carbonyls.
Keyword(s): Mannich-type reactions
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Diastereoselective three-component Mannich reaction catalyzed by prolinated MWCNTs
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| contributor author | مهسا خوشنویس | en |
| contributor author | حسین عشقی | en |
| contributor author | مهدی بکاولی | en |
| contributor author | Mahsa khoshnevis | fa |
| contributor author | Hossein Eshghi | fa |
| contributor author | Mehdi Bakavoli | fa |
| date accessioned | 2020-06-06T14:29:18Z | |
| date available | 2020-06-06T14:29:18Z | |
| date copyright | 7/17/2018 | |
| date issued | 2018 | |
| identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3398803?locale-attribute=en | |
| description abstract | Asymmetric Mannich and Mannich-type reactions are important carbon-carbon bond- -amino carbonyl derivatives.[1] -lactam and - -amino acid derivatives, peroxy acetylenic alcohols/ethers, and medicinally important materials. Several strategies[2,3] are -amino carbonyl compounds, including organocatalysis transition-metal catalysis, Bronsted and Lewis acid catalysis, phasetransfer catalysis, biocatalysis and ionic-liquid catalysis. Herein we report a highly anti-diastereoselective three-component Mannich reaction of aromatic amines and aldehydes with cyclohexanone in water as solvent and efficient nano organocatalyst. Reusability, easy workup, inexpensive, ready availability, short reaction time and its high diastereoselctivity 70-100% makes this catalyst an attractive alternative to the existing catalyst -amino carbonyls. | en |
| language | English | |
| title | Diastereoselective three-component Mannich reaction catalyzed by prolinated MWCNTs | en |
| type | Conference Paper | |
| contenttype | External Fulltext | |
| subject keywords | Mannich-type reactions | en |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1071081.html | |
| identifier articleid | 1071081 |