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RISSynthesis of pyrimido[4′,5′:2,3][1,4]thiazepino[ 7,6-b]quinolines, derivatives of a novel ring system Abstract: Several derivatives of the novel pyrimido[4′,5′:2,3]
Several derivatives of the novel pyrimido[4′,5′:2,3] [1,4]thiazepino[7,6-b]quinoline ring system have been
synthesized through cyclocondensation of 5-amino-6-methylpyrimidine-4-thiols 5a,b and 2-chloroquinoline-
Synthesis of New Derivatives of 4-(4,7,7-Trimethyl-7,8-dihydro-6H-benzo [b]pyrimido[5,4-e][1,4]thiazin-2-yl)morpholine
Cyclocondensation of 5-amino-6-methyl-2-morpholinopyrimidine-4-thiol (1) and 2-bromo-5,5-dimethylcyclohexane-1,3-dione (2) under mild reaction condition afforded 4,7,7-trimethyl-2-morpholino-7,8-dihydro-5H-benzo[b]pyrimi ...
Synthesis and Biological Evaluation of New Derivatives of 7,8-dihydro-6Hbenzo[b]pyrimido[5,4-e][1,4]thiazine
Recently the synthesis of fused heterocyclic compounds possessing pyrimidothiazine as
central core has been interested for researchers because of possesing various biological properties such as antibacterial [1], ...
Synthesis of Pyranoquinolines from One-Pot Imino-Diels-Alder Reaction catalyzed by LaCl3.7H2O
The Hetero-Diels-Alder reaction is one of the most powerful synthetic routes for constructing nitrogen containing sixmembered heterocycles [1]. In recent years, increasing attention has been given to the synthesis of ...
Synthesis of new derivatives ofdipyrimido[4,5-b:5,4-e][1,4]thiazine and their enzyme inhibitory activity assessment on soybean 15-lipoxygenase
Pyrimidine derivatives and annulated pyrimidines continue to attract great interest because of their wide variety of interesting biological activities, such as anticancer [1], antiviral [2], antitumor [3], and anti-inflammatory ...
Synthesis of Novel Heterocyclic System: 1,2-bis-[3-(2- [1,2,4]triazolo[3\\\\\\\\\\\\\\',4\\\\\\\\\\\\\\':2,3][1,3,4]thiadiazepino[7,6-b]quinolin-3-yl]ethane
The tiadizepine nucleus is a pharmacophoric scaffold and represents a class of
heterocycles with a wide range of biological applications. Many of them are widely used
as anticonvulsant, antianxiety, sedative, ...
Synthesis of Novel Heterocyclic System: Pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinoline
Heterocycles containing the thiazepine moiety are important targets in synthetic and
medicinal chemistry because this fragment is a key moiety in a wide number of natural
and synthetic biologically active ...
Biological Evaluation and Docking Studies of 3,5-Bis ((5-bromo-6-methyl-2-taminopyrimidin-4-yl)thio)-4H-1,2,4-triazol-4-aminesas 15- Lipoxygenase Inhibitors
Triazoles and their derivatives play important roles in medicinal fields [1]. More over pyrimidine derivatives are highly effective as hypnotic drugs, antitumor, antibacterial agents and in cancer detection. Recently, ...
Theoretical and Experimental Enzyme Inhibitory Evaluations of New Derivatives of Dipyrimido[4,5-b:5,4-e][1,4]thiazine on Soybean 15-Lipoxygenase
In recent years, the synthesis of fused heterocyclic compounds possessing pyrimidothiazine as central core has been the focus of great interest [1]. It has been recently reported that these compounds show inhibitory effect ...
Synthesis and Evaluation of a New Series of 3,5-bis ((5-bromo-6-methyl-2- t-aminopyrimidin-4-yl)thio)-4 H-1,2,4-triazol-4-amines and their Cyclized Products ‘Pyrimidinylthio Pyrimidotriazolothiadiazines’ as 15- Lipo-Oxygenase Inhibitors
A series of new 3,5-bis((5-bromo-6-methyl-2- t -aminopyrimidin-4 -yl)thio)-4 H-1,2,4-triazol-4-amines and their cycliz ed products ‘pyrimidinylthio pyrimidotriazolothiadiazi nes’ were designed, synthesized, and evaluated ...