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RISSynthesis of pyrimido[4′,5′:2,3][1,4]thiazepino[ 7,6-b]quinolines, derivatives of a novel ring system Abstract: Several derivatives of the novel pyrimido[4′,5′:2,3]
Several derivatives of the novel pyrimido[4′,5′:2,3] [1,4]thiazepino[7,6-b]quinoline ring system have been
synthesized through cyclocondensation of 5-amino-6-methylpyrimidine-4-thiols 5a,b and 2-chloroquinoline-
3-carbaldehydes 6a...
H eterogeneity of protein labeling with a fluorogenic reagent, 3-(2-furoyl)quinoline-2-carboxaldehyde
fluorogenic reagent on the
acid–base properties of the protein. The fluorogenic reagent used was 3-(2-furoyl)quinoline-2-carboxaldehyde (FQ). In
slab-gel isoelectric focusing, we found that the labeling reaction generated at least six species...
Synthesis and Docking Analysis of New Heterocyclic System N1, N4-bis ((2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor
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Arg 225 and Trp 76 via quinoline moiety and nitrogen of quinolone ring (Figure 1.). pi-pi
interaction between Lys 220, Trp 76, Tyr 224, Arg 225, Ile 80, and Asn 49 quinoline moiety was
one of the common factor in enzyme-inhibitor junction...
Synthesis of quinolones derivatives in the presence of CsI as a catalyst
Quinoline is a well-known structural unit in several natural compounds (cincona alkaloids) and synthetic analogues with interesting biological activities [1]. The biological activity of quinoline derivatives has been found to possess antiasthmatic...
Microanatomical evidences for potential of mesenchymal stem cells in amelioration of striatal degeneration
mesenchymal stem cells
in amelioration of striatal degeneration was assessed in animal model of Huntington’s disease.
After unilateral lesion in striatum was caused by quinolinic acid (QA), bone marrow derived
mesenchymal stem cells, which...
Histopathological and Behavioral Assessment of Toxin-Produced Cerebellar Lesion: A Potent Model for Cell Transplantation Studies in Cerebellum
in contemporary motor and cognitive abnormalities.
Methods: Slow administration of Quinolinic acid (QA, 5μl of 200 μmol, 1μl/minute) in the right cerebellar hemisphere (lobule VI) caused noticeable motor and cognitive disturbance and cellular degeneration...
Synthesis and docking analysis of new heterocyclic system of tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b]quinolines as aldose reductase inhibitors
Objective(s): In recent years, the chemistry of Tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b] quinolines have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological...
Synthesis and docking analysis of new 2-chloro-3-((2,2-dimethylhydrazono) methyl)quinoline derivatives as non-nucleoside human HIV-1 reverse transcriptase inhibitors
-((2,2-dimethylhydrazono)methyl)quinoline derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological effects as non-nucleoside Human HIV-1 Reverse Transcriptase Inhibitors. A group of 2-chloro- 3-((2,2-dimethylhydrazono)methyl) quinolone...
Direct C2-arylation of Quinoline N-Oxides by Boronic Esters; A Molecular Approach on the Efficient Metal-free Method in C-C Cross-coupling Reactions
Kinetic and thermodynamic aspects of the cross-coupling reaction of quinoline N-oxides by various boronic esters in the gas and solvent phases were investigated, theoretically. Two types of boronic esters were considered for the reaction...
Synthesis of Novel Heterocyclic System: Pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinoline
-d) with (2) in
boiling N-N-di-methylformamide (DMF), in the presence of Et3N, afforded
pyrimido[4,5:2,3][1,4]thiazepino[7,6-b]quinoline (3a-f) as the main products.
Consequently, the biological activities of these compounds are also...