One-pot solvent free synthesis of someindolylmethane amine derivativesbyFe(HSO4)3 as a recycable catalyst
نویسنده:
, , , , ,سال
: 2013
چکیده: In recent years, significant interest has been devoted to the preparation of substituted indoles due to their varied biological activities including antioxidant, antibacterial, and insecticidal. They also act as colon cancer cell and tumor growth inhibitors and are employed as valuable antibiotics.[1,2]
Despite several methods available in the literature for the synthesis of substituted indoles, there are only a few reports on the access of substituted 3-aminoalkylated indoles using Multi Component Reactions (MCR) protocols.[3,4]
In this work three-component reactions of indoles, benzaldehydes and N-alkylanilines in the presence of an acid catalyst, such as ferric hydrogensulfate (FHS) as a recyclable, easy synthesized and inexpensive catalyst.(Scheme 1)
Decreasing of reaction times, increasing of isolated yields, low percent of bisindolylmethaneformation as byproduct and solvent free conditions are the benefits of this method by means of FHS as catalyst.
Despite several methods available in the literature for the synthesis of substituted indoles, there are only a few reports on the access of substituted 3-aminoalkylated indoles using Multi Component Reactions (MCR) protocols.[3,4]
In this work three-component reactions of indoles, benzaldehydes and N-alkylanilines in the presence of an acid catalyst, such as ferric hydrogensulfate (FHS) as a recyclable, easy synthesized and inexpensive catalyst.(Scheme 1)
Decreasing of reaction times, increasing of isolated yields, low percent of bisindolylmethaneformation as byproduct and solvent free conditions are the benefits of this method by means of FHS as catalyst.
کلیدواژه(گان): In recent years,significant interest has been devoted to the preparation of substituted indoles due to their varied biological activities including antioxidant,antibacterial,and insecticidal,They also act as colon cancer cell and tumor growth inhibito
کالکشن
:
-
آمار بازدید
One-pot solvent free synthesis of someindolylmethane amine derivativesbyFe(HSO4)3 as a recycable catalyst
Show full item record
contributor author | حسین عشقی | en |
contributor author | مجید مکبر اصفهانی | en |
contributor author | محمد رحیمی زاده | en |
contributor author | Hossein Eshghi | fa |
contributor author | majid mokaber | fa |
contributor author | Mohammad Rahimizadeh | fa |
date accessioned | 2020-06-06T14:10:31Z | |
date available | 2020-06-06T14:10:31Z | |
date copyright | 7/3/2013 | |
date issued | 2013 | |
identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3385577?locale-attribute=fa | |
description abstract | In recent years, significant interest has been devoted to the preparation of substituted indoles due to their varied biological activities including antioxidant, antibacterial, and insecticidal. They also act as colon cancer cell and tumor growth inhibitors and are employed as valuable antibiotics.[1,2] Despite several methods available in the literature for the synthesis of substituted indoles, there are only a few reports on the access of substituted 3-aminoalkylated indoles using Multi Component Reactions (MCR) protocols.[3,4] In this work three-component reactions of indoles, benzaldehydes and N-alkylanilines in the presence of an acid catalyst, such as ferric hydrogensulfate (FHS) as a recyclable, easy synthesized and inexpensive catalyst.(Scheme 1) Decreasing of reaction times, increasing of isolated yields, low percent of bisindolylmethaneformation as byproduct and solvent free conditions are the benefits of this method by means of FHS as catalyst. | en |
language | English | |
title | One-pot solvent free synthesis of someindolylmethane amine derivativesbyFe(HSO4)3 as a recycable catalyst | en |
type | Conference Paper | |
contenttype | External Fulltext | |
subject keywords | In recent years | en |
subject keywords | significant interest has been devoted to the preparation of substituted indoles due to their varied biological activities including antioxidant | en |
subject keywords | antibacterial | en |
subject keywords | and insecticidal | en |
subject keywords | They also act as colon cancer cell and tumor growth inhibito | en |
identifier link | https://profdoc.um.ac.ir/paper-abstract-1035436.html | |
conference title | 20th Iranian Seminar of Organic Chemistry | en |
conference location | همدان | fa |
identifier articleid | 1035436 |