Application of phiC31 integrase system in stem cells biology and technology: a review
Year
: 2018
Abstract: Two specific characteristics of stem cells, self-renewal and their differentiation capacity have made
them important for vast scientific areas, particularly in the molecular and cell biology of stem cells,
as well as regenerative medicine. Gene targeting plays a pivotal role in creating modified stem cells,
which are considered the mainstay in regenerative medicine. The phiC31 integrase system, as a sitespecific recombinase, could be a straightforward and efficient approach for this aim. According to the
high potential of the application of phiC31 integrase system in stem cells, the present paper reviews
previous studies, placing the focus on stem cell types and their application.
them important for vast scientific areas, particularly in the molecular and cell biology of stem cells,
as well as regenerative medicine. Gene targeting plays a pivotal role in creating modified stem cells,
which are considered the mainstay in regenerative medicine. The phiC31 integrase system, as a sitespecific recombinase, could be a straightforward and efficient approach for this aim. According to the
high potential of the application of phiC31 integrase system in stem cells, the present paper reviews
previous studies, placing the focus on stem cell types and their application.
Keyword(s): phiC31 integrase,stem cells,gene targeting,regenerative medicine
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Application of phiC31 integrase system in stem cells biology and technology: a review
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| contributor author | ادهم فانی ملکی | en |
| contributor author | محمدهادی سخاوتی | en |
| contributor author | Adham Fani Maleki | fa |
| contributor author | Mohammad Hadi Sekhavati | fa |
| date accessioned | 2020-06-06T13:39:37Z | |
| date available | 2020-06-06T13:39:37Z | |
| date issued | 2018 | |
| identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3363932?locale-attribute=en | |
| description abstract | Two specific characteristics of stem cells, self-renewal and their differentiation capacity have made them important for vast scientific areas, particularly in the molecular and cell biology of stem cells, as well as regenerative medicine. Gene targeting plays a pivotal role in creating modified stem cells, which are considered the mainstay in regenerative medicine. The phiC31 integrase system, as a sitespecific recombinase, could be a straightforward and efficient approach for this aim. According to the high potential of the application of phiC31 integrase system in stem cells, the present paper reviews previous studies, placing the focus on stem cell types and their application. | en |
| language | English | |
| title | Application of phiC31 integrase system in stem cells biology and technology: a review | en |
| type | Journal Paper | |
| contenttype | External Fulltext | |
| subject keywords | phiC31 integrase | en |
| subject keywords | stem cells | en |
| subject keywords | gene targeting | en |
| subject keywords | regenerative medicine | en |
| journal title | Frontiers in Life Science | fa |
| pages | 10-Jan | |
| journal volume | 11 | |
| journal issue | 1 | |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1067929.html | |
| identifier articleid | 1067929 |