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RISSynthesis of novel chiral acylating agents: Isoindoline-1,3-diones
Chiral heterocycles have been described as interesting biologically active agents [1]. Recently, we reported the synthesis of some chiral heterocyles through incorporation of chiral amino acids onto the heterocyclic rings ...
Alternative route for the synthesis of new derivatives of benzimidazo[2’,1’:2,3] thiazolo[5,4-d]pyrimidine
A series of new benzimidazothiazolopyrimidines were synthesised through a route involving successive nucleophilic substitution of
5-bromo-2,4-dichloro-6-methylpyrimidine with 2-mercaptobenzimidazole and secondary ...
Synthesis of new pyrimido [4,5-e][1,2,4] triazolo [3,4-b][1,3,4] thiadiazine derivatives via S/N Smiles rearrangement
Several new pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives (5a–g) were synthesized through the condensation reaction of 5-bromo-4,6-dichloropyrimidine (1) and 4-amino-5-methyl-4H-1,2,4triazole-3-thiol(2). ...
Synthesis of 5,5-(ethane-1,2-diyl) bis (3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl) thio)-4H-1,2,4-triazol-4-amines) and Their Novel bis-cyclized Products, 1,2-bis (pyrimido [5,4e] [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazin-3-yl) ethane, as Potent
Several new derivatives of 5,5′-(ethane-1,2-diyl)bis(3-((5-bromo-6-methyl-2-tertiaryamino pyrimidin-4yl)thio)-4H-1,2,4-triazol-4-amine)(4a–f) and their novel cyclized products, 1,2-bis(pyrimido[5,4-e][1,2,4]
triaz ...
Synthesis, X-ray and Fluorescence Characteristics of Pyrimido[5,4-e]thiazolo[3,2-a]pyrimidine as a Novel Heterocyclic System
Derivatives of a new heterocyclic system, pyrimido[5,4-e]thiazolo[3,2-a]pyrimidine 3, were prepared
by sequential treatment of ethyl 4 - chloro - 2-(methylthio)pyrimidine-5-carboxylate 1 with 4,5-
dihydroth ...
Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents
In recent years, pyrazolo[3,4-d]pyrimidines and related fused heterocyclic compounds have attracted the attention of numerous researchers due to their important biological activities and their structure similarity to ...
Synthesis of Novel Heterocyclic System: 1,2-bis-[3-(2- [1,2,4]triazolo[3\\\\\\\\\\\\\\',4\\\\\\\\\\\\\\':2,3][1,3,4]thiadiazepino[7,6-b]quinolin-3-yl]ethane
The tiadizepine nucleus is a pharmacophoric scaffold and represents a class of
heterocycles with a wide range of biological applications. Many of them are widely used
as anticonvulsant, antianxiety, sedative, ...
Synthesis of Some Novel 1,3,4-Thiadiazine Containing Triazolo and Pyrazolo Nucleus
1,3,4-Thiadiazines represent the most widely studied class of compounds among the six
theoretically possible thiadiazine isomers; they are of interest in a chemical sense
because they are labile compounds ...
Synthesis of new derivatives of pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and stadise of their biological activities
Due to their unique clinical applications, syntheses of pyrimidine-fused heterocycles have been intensively investigated in recent years. Pyrimidine derivatives are highly effective as hypnotic drugs, antitumor, antibacterial ...
Synthesis of Novel Heterocyclic System: Pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinoline
Heterocycles containing the thiazepine moiety are important targets in synthetic and
medicinal chemistry because this fragment is a key moiety in a wide number of natural
and synthetic biologically active ...