Background: Many crucial cellular operations such as metabolism, signalling, and regulations are based on protein-protein interactions. However, the lack of robust protein-protein interaction information is a challenge. ...

Protein domains are conserved and functionally independent structures that play an important role in interactions among related proteins. Domain-domain interactions have been recently used to predict protein-protein ...

Metabolic bionetwork of Caenorhabditis elegans has been reconstructed using genome information retrieved from KEGG (Kyoto Encyclopedia of Genomes and Genes, Release 32) database. The reconstructed bionetwork contains 103 ...

C. elegans has over 7000 genes in common with the human genome. Many biological processes inside human genome are similar to that in C. elegans, making it a promising ‘candidate’ for studying human-related diseases. with ...

Abstract

Signatures are functional sub-units of proteins’ primary structures. They include domains, motifs, and binding sites. Signatures play an important role in determining the interactions web of a particular ...

Protein-protein interaction is the key element of cellular activities. Proteins interact with each other through functional units such as domains, binding sites, etc which are collectively called signatures. Signatures are ...