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RIS15-Lipoxygenase inhibitors: A patent review
Introduction: 15-Lipoxygenases (15-LOXes) are a family of iron-containingproteins that have the capability for unsaturated fatty acid peroxidation inanimals and plants. Two types of the enzyme, 15-LOX-1 and 15-LOX-2, ...
Synthesis of new series of α-cyclodextrin esters as dopamine carrier molecule
A new series of amphiphilic α-cyclodextrins were synthesized by grafting N-acylated amino acids [valine, leucine, phenylalanine, methionine, and tryptophan (3a–e)] to the primary hydroxyl groups via ester bond formation. ...
Design and Synthesis of Novel Series of 8-prenyloxy coumarin-3-Carboxylic acid as 15-Lipoxygenase Inhibitors
15-Lipoxygenases are one of the non hem iron-containing proteins with ability of unsaturated lipid peroxidation in animals and plants. The critical role of the enzymes in formation of inflammations, sensitivities and some ...
Design and synthesis of a new series of amphiphilic peptide-β-cyclodextrins as phase transfer carriers for glucosamine
A new series of amphiphilic β-cyclodextrins were designed and synthesized by grafting peptide chains on to all primary hydroxyl groups via ester bond formation. The desired amphiphilic structures have been produced from ...
Synthesis and SAR comparative studies of 2-allyl-4-methoxy-1-alkoxybenzenes as 15-lipoxygenase inhibitors
A group of 2-alkoxy-5-methoxyallylbenzene were designed, synthesised and evaluated as potential inhibitors of the soybean 15-lipoxygenase (SLO) on the basis of the eugenol and esteragol structures. Compound 4d showed the ...
Synthesis of new heterocyclic system: 2-substituted-4-methyl-5,11dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine
The development of heterocyclic scaffolds is a fast emerging subject in medicinal chemistry. Among these, benzo-fused sulfurated seven-membered lactams are endowed with a large spectrum of biological activities with a wide ...
LaCl3.7H2O: an efficient Lewis acid catalyst for synthesis N-(benzothiazole-2-yl)- O,O-dimethyl-α-aminophosphonates
A three-component synthesis of α- aminophosphonate is described from a reaction between aldehydes, 2-aminobenzothiazole, and trimethyl phosphite in the presence of LaCl3.7H2O as a catalyst under solvent-free conditions for ...
2-Prenylated m -Dimethoxybenzenes as Potent Inhibitors of 15-Lipoxygenase: Inhibitory Mechanis m and SAR studies
15-lipo-oxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, ...
Synthesis and antibacterial activities of new fluoroquinolones based on ciprofloxacin structure
Since the discovery of the antibacterial penicillium, there has been a huge interest in finding new natural and synthetic organic compounds with antibacterial activity.[1] Nalidixic acid was the first quinolone used as ...