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RISAn Alternative Regioselective Approach for the Synthesis of Highly Functionalized Derivatives of Pyrazolo[5,1-b]purine Scaffold
A straightforward approach for the regioselective synthesis of highly functionalized pyrazolo[5,1-b]purine
from the annulation of 6-bromo-3-cyano-2-(ethylthio)-5-methyl-7-oxo-6,7-dihydropyrazolo[1,5-a]pyrimidine
with ...
Synthesis of Novel Derivatives of Pyrazolo[5,1-b]purine: A Straightforward Approach
Introduction: Purine is a privileged nitrogen-containing heterocycle which exists in various bioactive compounds. The biological importance of purines has led to an interest in synthesis of them with pharmaceutical properties ...
One-pot procedure for the synthesis of diverse derivatives of novel heterocyclic system benzo[e]pyrazolo[5',1':2,3]pyrimido[5,4- b][1,4]diazepine
The 1,4-diazepine and 1,4-benzodiazepine structures have been found in the naturally
occurring products and are significant biomolecules in medicinal chemistry with a wide
range of biological and pharmacological ...
A One-Pot Procedure for the Synthesis of Highly Functionalized Derivatives of a Novel Five-Cyclic Scaffold: Pyrazolo[ 5\\'\\',1\\'\\':2\\',3\\']pyrimido[4\\',5\\':5,6][1,4]thiazino[2,3-b]quinoxaline
Quinoxalines display a broad spectrum of biological and pharmacological activities such as
insecticides, fungicides, herbicides, antibacterial, antimycobacterial, antiprotozoal and anticancer
properties [1]. ...
A straightforward approach for the synthesis of diverse derivatives of a novel selenium containing heterocyclic system [1,3]selenazolo[4,5-d]pyrimidine-5(4H)-thione using phenyl isothiocyanates
In the recent years, selenazoles have been reported to have very unique chemical and biological properties such as inactivation of free radicals,1 antioxidant,2 cancer cell proliferation 3 and protein kinase activation 4. ...
Synthesis of various derivatives of [1,3]selenazolo[4,5-d]pyrimidine as a novel selenazolocondenced heterocyclic system
Selenium used to be considered as an essential nutrient, constituent of selenoproteins involved in self-defense mechanism against oxidative stress,1 in reducing certain inflammatory processes and in detoxification processes ...
A Straightforward Approach for the Synthesis of Novel Derivatives of Benzo [b] pyrazolo [5,1: 2,3] pyrimido [4, 5-e] [1,4] thiazine
Several derivatives of the novel benzo[b]pyrazolo[5′,1′:2,3]pyrimido[4,5-e][1,4]thiazine ring system have been synthesized through the one-pot cyclocondensation of 6-bromo-7-chloro-2-(ethylthio)5-methylpyrazolo[1,5-a]pyr ...
Synthesis of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine
A number of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine have been synthesised by cyclocondensation of several
hydrazino derivatives of pyrazolo[3,4-d]pyrimidine with either orthoesters or ...
Synthesis of new derivatives of pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine; a novel heterocyclic system
Several derivatives of the novel pyridazino[6,1-c]pyrimido[5,4-e][1,2,4]triazine ring system have been synthesised through heterocyclisation of 5-bromo-2,4-dichloro-6-methylpyrimidine with 3-chloro-6-hydrazinylpyridazine ...
Synthesis of various S-alkylated derivatives of newly synthesized tricyclic selenium containing heterocyclic system
Selenium is a micronutrient essential for mammals. It plays a crucial role in the
mammalian defense system against oxidative stress, since it is essential for the activity
of glutathione peroxidase (GPx). It ...