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RISCloning, Molecular Analysis and Epitopes Prediction of BLS Gene from B. Melitensis
Brucellosis is a well known infection among domestic animals caused by Brucella bacterium. The objective of the present study was to clone, sequence analysis and epitopes prediction of BLS gene as major B. melitensis ...
Isolation, cloning and expression of the Brucella melitensis Omp31 gene
, and the Middle East have currently been listed as high-risk regions. The genus Brucella is classified in at least nine species. Brucella melitensis is the global pathogenic species of Brucella. The outer membrane protein 31, (Omp31) from B. melitensis...
Design and Production of a Novel Recombinant Chimeric IL2-Omp31 Antigen against Brucella Infection
Brucellosis is a zoonotic disease in human and animals. Brucella melitensis is one of the most pathogenic
species of Brucella in goat and sheep. Omp31 is an outer membrane protein of Brucella that acts as an
immunogenic protein...
In silico cloning and bioinformatics study of Brucella melitensis Omp31 antigen in different mammalian expression vectors
Brucella melitensis, as a pathogenic gram-negative intracellular bacterium, causes brucellosis in animals and humans. According to literature, the B. melitensis outer membrane protein 31 (Omp31) is considered as an important vaccine candidate...
Comparative gene expression analysis on THP-1 macrophages infected with Brucella melitensis or Listeria monocytogenes
Brucella melitensis or Listeria
monocytogenes we studied the expression levels of four host genes i.e. EMP2,
ST8SIA4, HCP and FRMD5 known to be involved in pathogenesis of Mycobacterium
tuberculosis. Brucella melitensis and Listeria...
In silico analysis of Omp25 and BLS Brucella melitensis antigens for designing subunit vaccine
vaccines based on Brucella outer membrane protein (OMP) antigens. The objectives of the present study were cloning, sequencing and epitope prediction of Omp25 and BLS genes as two major Brucella melitensis antigens. The full-length open reading frame (ORF...
Cloning and molecular characterization of Omp31 gene from Brucella melitensis Rev 1 strain
Brucellosis, caused by the genus Brucella bacterium, is a well-known infection among domestic animals.
Considering the serious economic and medical consequences of this infection, various preventive efforts have ...
Cloning, expression and molecular analysis of Iranian Brucella melitensis Omp25 gene for designing a subunit vaccine
Brucellosis is a well-known domestic animal infectious disease, which is caused by Brucella bacterium. The
outer membrane protein 25 kDa (Omp25) gene plays an important role in simulating of TNF-α, IFN-α,
macrophage, ...
Designing a Novel Chimeric Antigen to Stimulate the Immune System against Brucella Infection
Brucellosis is a well-known infectious disease among domestic animals caused by Brucella bacterium. OMP25 is an outer membrane protein of Brucella which plays an important role in immunogenicity of cells. Moreover, Brucella ...
Immunogenicity evaluation of plasmids encoding Brucella melitensis Omp25 and Omp31 antigens in BALB/c mice
Objective(s): Vaccination is one of the most effective means to protect humans and animals against brucellosis. Live attenuated Brucella vaccines are considered effective in animals but they may be potentially infectious ...