Thiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluation
| contributor author | محمد رحیمی زاده | en |
| contributor author | مهدی بکاولی | en |
| contributor author | علی شیری | en |
| contributor author | ریحانه فریدنیا | en |
| contributor author | پروانه پردلی | en |
| contributor author | Fatemeh Oroojalian | en |
| contributor author | Mohammad Rahimizadeh | fa |
| contributor author | Mehdi Bakavoli | fa |
| contributor author | Ali Shiri | fa |
| contributor author | Parvaneh Pordeli | fa |
| date accessioned | 2020-06-06T14:35:50Z | |
| date available | 2020-06-06T14:35:50Z | |
| date issued | 2011 | |
| identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3403364?show=full | |
| description abstract | The reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine ( 1 ) with carbon disulfi de in the presence of KOH in DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5- d ] pyrimidine-2 (3 H )-thione ( 2 ) which was then alkylated at the sulfur atom with various alkyl halides in the presence of Et 3 N in acetonitrile to give alkylthio derivatives 3 . The substitution of the chlorine atom in 3 with morpholine was also investigated. The synthesized compounds were subjected to antibacterial evaluations. | en |
| language | English | |
| title | Thiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluation | en |
| type | Journal Paper | |
| contenttype | External Fulltext | |
| subject keywords | antibacterial evaluation | en |
| subject keywords | heterocyclization | en |
| subject keywords | thiazolo[4 | en |
| subject keywords | 5-d]pyrimidine | en |
| journal title | Heterocyclic Communications | fa |
| pages | 43-47 | |
| journal volume | 17 | |
| journal issue | 1 | |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1022607.html | |
| identifier articleid | 1022607 |
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