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contributor authorمحمد رحیمی زادهen
contributor authorمهدی بکاولیen
contributor authorعلی شیریen
contributor authorریحانه فریدنیاen
contributor authorپروانه پردلیen
contributor authorFatemeh Oroojalianen
contributor authorMohammad Rahimizadehfa
contributor authorMehdi Bakavolifa
contributor authorAli Shirifa
contributor authorParvaneh Pordelifa
date accessioned2020-06-06T14:35:50Z
date available2020-06-06T14:35:50Z
date issued2011
identifier urihttps://libsearch.um.ac.ir:443/fum/handle/fum/3403364?show=full
description abstractThe reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine

( 1 ) with carbon disulfi de in the presence of KOH in

DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5- d ]

pyrimidine-2 (3 H )-thione ( 2 ) which was then alkylated at the

sulfur atom with various alkyl halides in the presence of Et 3 N

in acetonitrile to give alkylthio derivatives 3 . The substitution

of the chlorine atom in 3 with morpholine was also investigated.

The synthesized compounds were subjected to antibacterial

evaluations.
en
languageEnglish
titleThiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluationen
typeJournal Paper
contenttypeExternal Fulltext
subject keywordsantibacterial evaluationen
subject keywordsheterocyclizationen
subject keywordsthiazolo[4en
subject keywords5-d]pyrimidineen
journal titleHeterocyclic Communicationsfa
pages43-47
journal volume17
journal issue1
identifier linkhttps://profdoc.um.ac.ir/paper-abstract-1022607.html
identifier articleid1022607


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