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contributor authorعلی اکبر حداد مشهد ریزهen
contributor authorAliakbar Haddad-Mashadrizehfa
date accessioned2020-06-06T14:24:08Z
date available2020-06-06T14:24:08Z
date copyright9/28/2016
date issued2016
identifier urihttps://libsearch.um.ac.ir:443/fum/handle/fum/3395139?show=full
description abstractCell surface antigens are critical markers for diagnostic and healing of many diseases such as

cancer. In this regard, mesothelin as specixc antigen, with low expression on the normal cells and

over-expression on the surface of mesothelioma, is suitable candidate for developing approaches of

therapeutic and diagnostic of cancer. Bearing in mind, the structural and functional

characterization as well as the expressing cells of the antigen was considered in this study for

immunotoxin development. Accordingly, the protein sequence of the mesothelin with the accession

number ALC62084 were retrieved from NCBI database. PROTEINATLAS were used for assessment the

expression of the antigen. On the other hand, corresponding specixc ligands of this antigen were

detected via STRING program. Structural modeling and quality assessment of the models were

carried out by MODELLER and RAMPAGE programs, respectively. Moreover, topology features of the

antigen were determined by Mpex program. All data were expressed as mean_standard deviation

with SPSS 21.0 (SPSS Inc., Chicago, IL, USA). Topology feature of the antigen showed that the C

terminal of the mesothelin is situating on the extracellular with one transmembrane region.

Moreover, various expression of the antigen were appeared on the surface of the mesothelial cells.

However, the highest expression of this antigen was determined on the surface of ovarian cancer

cells. Furthermore, 3D structure of the antigen showed 98% similarity with appropriate in quality.

Meanwhile, MUC19, WFDC2, WNT5A, NDUFB5, NDUFB9, MPV17, RALA, LAMTOR3, ZBTB43,

RNMTL1, HN1 and MOR Ab-009 propounded as corresponding ligands of the antigen with different

afxnity. In general, the results of this study provide the context for immunotoxins development

with the capacity to targeting mesothelin on the cell surface of the malignancies.
en
languageEnglish
titleAn Investigation On The Mesothelin Characteristics For Immunotoxin Developmenten
typeConference Paper
contenttypeExternal Fulltext
subject keywordsMUC19en
identifier linkhttps://profdoc.um.ac.ir/paper-abstract-1060651.html
conference title2nd International Nastaran Cancer Symposiumen
conference locationمشهدfa
identifier articleid1060651


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