Bioinformatic analysis of Tuberculosis Dnak protein

Abstract

Tuberculosis (TB) is an infectious disease that usually infects the lungs, but can attack almost any part of the body. Du to<br><br>serious medical consequences of this disease various efforts have been made to prevent the infection through the use of<br><br>recombinant vaccines based on) Tuberculosis antigens. The objective of this study was to obtain the bioinformatics<br><br>characteristics of Dnak antigen. Up to this, online prediction software applications were used such as: T-cells epitopes<br><br>prediction, secondary and 3D structures and antigenicity ability. Bioinformatics analysis identified T-cell epitopes locations<br><br>at 232-257 sand 363-373 amino acid. Bioinformatics analysis showed that this region had proper epitope characterization<br><br>and so it seems to be useful for developing of vaccine based epitope design