Bovine MHC Class II Structure-Function Relationships: Implications for Vaccine Development

Abstract

T cell mediated immunoregulation plays an important role in protective immunity. The central molecular<br><br>interaction, which dictates the selection of the specificity of T cells, depends on the interaction between MHC<br><br>molecules and peptides derived from degraded antigenic structures. Here, we studied this interaction between<br><br>bovine MHC class II molecules and peptides derived from foot and mouth disease virus (FMDV). Progress<br><br>during the last decade in our understanding of the mechanisms underlying antigen recognition by T lymphocytes,<br><br>opens the possibility to apply this knowledge in new approaches for the development of vaccines.