Fabrication of a new electrochemical sensor based on AuePt bimetallic nanoparticles decorated multi-walled carbon nanotubes for determination of diclofenac

Abstract

A new electrochemical sensor was developed for determination of diclofenac based on functionalized multiwalled<br><br>carbon nanotubes (f-MWCNTs) and gold–platinum bimetallic nanoparticles (Au–PtNPs) modified gold<br><br>electrode. The Au–PtNPs were deposited electrochemically on the surface of the f-MWCNTs modified electrode.<br><br>The surface morphologies of the modified electrodes were investigated by scanning electron microscopy (SEM)<br><br>and energy dispersive X-ray spectroscopy (EDX). Cyclic voltammetry (CV) and differential pulse voltammetry<br><br>(DPV) were used to evaluate the electrochemical properties of the constructed sensor. Under the optimized<br><br>experimental conditions, the calibration curve was linear in the concentration range of 0.5 μM to 1000 μM of<br><br>diclofenac and the detection limit was found to be 0.3 μM. The developed electrode also showed a high selectivity for diclofenac in the presence of the interfering species. The reproducibility, repeatability and stability<br><br>of the electrode were satisfactory. The proposed electrochemical sensor was successfully employed for determination of diclofenac in real samples such as tablet and human urine samples.