The Impact of Brevinin-2R Peptide on Oxidative Statues and Antioxidant Enzymes in Human Epithelial Cell Line of A549
سال
: 2018
چکیده: Antioxidant enzymes protect cells against reactive oxygen species. The level of antioxidant enzymes is reduced almost in
cancer cells. The effect of brevinine-2R (B2R) peptide on antioxidant enzyme activities in A549 cell line were investigated
and results compared with glutathione (GSH). Catalase, superoxide dismutase (SOD) and glutathione peroxidase of A549
extract cells had their most activities in treated cells at 4.8 μM of B2R and 9.5 μM of GSH for 24 h. Cell attachment was also
increased in the presence of B2R and GSH peptide. Thiol status, antioxidant capacity and reactive oxygen species (ROS) of
the treated A549 cells were measured. B2R showed its most ROS level, antioxidant capacity and thiol status in the treated
cells at 4.8 μM of peptide. B2R peptide like GSH has cytoprotective effect on A549 cells by strengthening the cellular antioxidant
system thereby confirming potential pharmaceutical property of the peptide
cancer cells. The effect of brevinine-2R (B2R) peptide on antioxidant enzyme activities in A549 cell line were investigated
and results compared with glutathione (GSH). Catalase, superoxide dismutase (SOD) and glutathione peroxidase of A549
extract cells had their most activities in treated cells at 4.8 μM of B2R and 9.5 μM of GSH for 24 h. Cell attachment was also
increased in the presence of B2R and GSH peptide. Thiol status, antioxidant capacity and reactive oxygen species (ROS) of
the treated A549 cells were measured. B2R showed its most ROS level, antioxidant capacity and thiol status in the treated
cells at 4.8 μM of peptide. B2R peptide like GSH has cytoprotective effect on A549 cells by strengthening the cellular antioxidant
system thereby confirming potential pharmaceutical property of the peptide
کلیدواژه(گان): Antioxidant enzymes · Brevinine-2R · Cell attachment · Human epithelial adenocarcinoma cell line · Reactive
oxygen species · Total thiol
کالکشن
:
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آمار بازدید
The Impact of Brevinin-2R Peptide on Oxidative Statues and Antioxidant Enzymes in Human Epithelial Cell Line of A549
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| contributor author | بهاره قدسی مقدم | en |
| contributor author | احمد آسوده | en |
| contributor author | bahareh ghodsi moghadam | fa |
| contributor author | Ahmad Asoodeh | fa |
| date accessioned | 2020-06-06T13:41:27Z | |
| date available | 2020-06-06T13:41:27Z | |
| date issued | 2018 | |
| identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3365188 | |
| description abstract | Antioxidant enzymes protect cells against reactive oxygen species. The level of antioxidant enzymes is reduced almost in cancer cells. The effect of brevinine-2R (B2R) peptide on antioxidant enzyme activities in A549 cell line were investigated and results compared with glutathione (GSH). Catalase, superoxide dismutase (SOD) and glutathione peroxidase of A549 extract cells had their most activities in treated cells at 4.8 μM of B2R and 9.5 μM of GSH for 24 h. Cell attachment was also increased in the presence of B2R and GSH peptide. Thiol status, antioxidant capacity and reactive oxygen species (ROS) of the treated A549 cells were measured. B2R showed its most ROS level, antioxidant capacity and thiol status in the treated cells at 4.8 μM of peptide. B2R peptide like GSH has cytoprotective effect on A549 cells by strengthening the cellular antioxidant system thereby confirming potential pharmaceutical property of the peptide | en |
| language | English | |
| title | The Impact of Brevinin-2R Peptide on Oxidative Statues and Antioxidant Enzymes in Human Epithelial Cell Line of A549 | en |
| type | Journal Paper | |
| contenttype | External Fulltext | |
| subject keywords | Antioxidant enzymes · Brevinine-2R · Cell attachment · Human epithelial adenocarcinoma cell line · Reactive oxygen species · Total thiol | en |
| journal title | International Journal of Peptide Research and Therapeutics | fa |
| pages | 0-0 | |
| journal volume | 0 | |
| journal issue | 0 | |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1069806.html | |
| identifier articleid | 1069806 |