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contributor authorالناز بای رودیen
contributor authorراضیه جلالen
contributor authorElnaz Bairudifa
contributor authorRazieh Jalalfa
date accessioned2020-06-06T13:30:42Z
date available2020-06-06T13:30:42Z
date issued2016
identifier urihttps://libsearch.um.ac.ir:443/fum/handle/fum/3357920?show=full
description abstractBackground and Objectives: Bacterial resistance to conventional antibiotics has become a widespread public health problem.

The aim of this study was to investigate the influence of zinc oxide nanoparticles (ZnO NPs) on the antibacterial activity of several conventional antibiotics against Pseudomonas aeruginosa.

Materials and Methods: ZnO NPs were prepared by solvothermal method and dispersed in glycerol with the help of ammonium citrate as a dispersant. The antibacterial effects of the resulting ZnO nanofluid, ceftazidime, tobramycin, and ciprofloxacin were investigated against two P. aeruginosa strains, including one clinical isolate and P. aeruginosa ATCC 9027 using microdilution method. For the evaluation of the combined effect of ZnO nanofluid and antibiotics, the fractional inhibitory concentration indices were calculated and isobolograms were plotted.

Results: Clinical strain in comparison to standard strain of P. aeruginosa showed more resistance to ZnO nanofluid and the antibiotics. ZnO nanofluid acted synergistically with ceftazidime and tobramycin against both strains. Combination of ZnO nanofluid and ciprofloxacin displayed synergistic and partial synergistic activity against clinical and standard strains of P. aeruginosa, respectively.

Conclusion: The results suggest that bacterial resistance to antimicrobials could be reduced by the synergistic action of ZnO NPs.
en
languageEnglish
titleModulation of antibiotic resistance in Pseudomonas aeruginosa by ZnO nanoparticlesen
typeJournal Paper
contenttypeExternal Fulltext
subject keywordsCeftazidimeen
subject keywordsCiprofloxacinen
subject keywordsPseudomonas aeruginosaen
subject keywordsTobramycinen
subject keywordsZnO nanoparticlesen
journal titleIranian Journal of Microbiologyfa
pages85-92
journal volume8
journal issue2
identifier linkhttps://profdoc.um.ac.ir/paper-abstract-1057807.html
identifier articleid1057807


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