The effect of magnesium sulfate in treatment of experimental oleander (Nerium oleander) poisoning in sheep
سال
: 2007
چکیده: The purpose of this study was evaluation of magnesium sulfate effect in treatment of acute
oleander intoxication in sheep. Eleven young native sheep randomly divided into 2 groups, 6
sheep being allocated to the treatment group and 5 served as controls. Sheep of both groups were
dosed with a lethal dose of 110mg/kg body weight of dried oleander leaves. In sheep of treatment
group, following development of ventricular arrhythmias, magnesium sulfate was slowly
administered intravenously with dose rate of 100mg/kg body weight. Clinical signs of toxicosis
were developed within 30 -40 minutes after dosing of the plant. Serial electrocardiography
revealed various abnormalities and arrhythmias of cardiac rhythm in sheep of control group.
Animals of control group died within 4.5 to 12 hours (median 8.5 hours) after receiving the toxic
material. Administration of magnesium sulfate in sheep of treatment group suppressed
ventricular arrhythmias to benign ones or normal sinus rhythm but its effect was transient and
persisted for 3 to 3.5 hours. Second injection of magnesium had same effect but there was no
considerable therapeutic effect after third injection of the drug. Sheep of treatment group died
within 18 to 34 hours (median 24.5 hours) after receiving the oleander. Statistical analysis
revealed a highly significant difference in survival time between the control and the treatment
groups (p<0.004). The results suggested that magnesium sulfate can be used as a complementary
therapeutic agent for treatment of acute oleander toxicosis in farm animals.
oleander intoxication in sheep. Eleven young native sheep randomly divided into 2 groups, 6
sheep being allocated to the treatment group and 5 served as controls. Sheep of both groups were
dosed with a lethal dose of 110mg/kg body weight of dried oleander leaves. In sheep of treatment
group, following development of ventricular arrhythmias, magnesium sulfate was slowly
administered intravenously with dose rate of 100mg/kg body weight. Clinical signs of toxicosis
were developed within 30 -40 minutes after dosing of the plant. Serial electrocardiography
revealed various abnormalities and arrhythmias of cardiac rhythm in sheep of control group.
Animals of control group died within 4.5 to 12 hours (median 8.5 hours) after receiving the toxic
material. Administration of magnesium sulfate in sheep of treatment group suppressed
ventricular arrhythmias to benign ones or normal sinus rhythm but its effect was transient and
persisted for 3 to 3.5 hours. Second injection of magnesium had same effect but there was no
considerable therapeutic effect after third injection of the drug. Sheep of treatment group died
within 18 to 34 hours (median 24.5 hours) after receiving the oleander. Statistical analysis
revealed a highly significant difference in survival time between the control and the treatment
groups (p<0.004). The results suggested that magnesium sulfate can be used as a complementary
therapeutic agent for treatment of acute oleander toxicosis in farm animals.
کلیدواژه(گان): Nerium oleander,sheep,cardiac glycosides,magnesium sulfate,arrhythmias
کالکشن
:
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آمار بازدید
The effect of magnesium sulfate in treatment of experimental oleander (Nerium oleander) poisoning in sheep
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contributor author | محمدرضا اصلانی | en |
contributor author | A. V. Heidari | en |
contributor author | Mohammad Reza Aslani | fa |
date accessioned | 2020-06-06T13:22:25Z | |
date available | 2020-06-06T13:22:25Z | |
date issued | 2007 | |
identifier uri | https://libsearch.um.ac.ir:443/fum/handle/fum/3352228 | |
description abstract | The purpose of this study was evaluation of magnesium sulfate effect in treatment of acute oleander intoxication in sheep. Eleven young native sheep randomly divided into 2 groups, 6 sheep being allocated to the treatment group and 5 served as controls. Sheep of both groups were dosed with a lethal dose of 110mg/kg body weight of dried oleander leaves. In sheep of treatment group, following development of ventricular arrhythmias, magnesium sulfate was slowly administered intravenously with dose rate of 100mg/kg body weight. Clinical signs of toxicosis were developed within 30 -40 minutes after dosing of the plant. Serial electrocardiography revealed various abnormalities and arrhythmias of cardiac rhythm in sheep of control group. Animals of control group died within 4.5 to 12 hours (median 8.5 hours) after receiving the toxic material. Administration of magnesium sulfate in sheep of treatment group suppressed ventricular arrhythmias to benign ones or normal sinus rhythm but its effect was transient and persisted for 3 to 3.5 hours. Second injection of magnesium had same effect but there was no considerable therapeutic effect after third injection of the drug. Sheep of treatment group died within 18 to 34 hours (median 24.5 hours) after receiving the oleander. Statistical analysis revealed a highly significant difference in survival time between the control and the treatment groups (p<0.004). The results suggested that magnesium sulfate can be used as a complementary therapeutic agent for treatment of acute oleander toxicosis in farm animals. | en |
language | English | |
title | The effect of magnesium sulfate in treatment of experimental oleander (Nerium oleander) poisoning in sheep | en |
type | Journal Paper | |
contenttype | External Fulltext | |
subject keywords | Nerium oleander | en |
subject keywords | sheep | en |
subject keywords | cardiac glycosides | en |
subject keywords | magnesium sulfate | en |
subject keywords | arrhythmias | en |
journal title | Iranian Journal of Veterinary Research | fa |
pages | 67-71 | |
journal volume | 4 | |
journal issue | 62 | |
identifier link | https://profdoc.um.ac.ir/paper-abstract-203576.html | |
identifier articleid | 203576 |