In this study, the activity of 15-LOX-1 was first evaluated in two prostate cancer cell lines PC3 and DU145. Considering the enzyme inhibitory potency of 5farnesyloxycoumarin (5f), the cytotoxic effects of this compound was ...

BACKGROUND:

Prostate cancer is one of the leading causes of cancer related deaths in males worldwide. Overexpression of 15-lipoxygenase-1 (15-LOX-1) enzyme and high activity of its metabolic pathway is reported to ...

Prostate cancer is one of the major health threatening cancers in men. At present, the usual clinical treatments of prostate cancer include surgery, radio and chemotherapy. The main chemotherapeutics agents includes steroidal ...

Prostate cancer is a heterogeneous disease that likely results frome a series of genetic events in the prostatic epithelial cells. In spite of major advances in cancer chemotherapy, effective responses have been obtained ...

سرطان پروستات دومین سرطان شایع و ششمین علت مرگ و میر سرطان در مردان می باشد. در سرطان پروستات، افزایش بیان آنزیم 15- لیپوکسیژناز نوع 1 مشاهده شده است. مشتقات فارنسیل اکسی کومارین از جمله مهار کننده های آنزیم 15 لیپواکسیژناز1 ...