Several derivatives of 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles were synthesized via Biginelli type reactionand evaluated fortheir anti-proliferative activity on human breast cancer (MCF-7) and ...

A facile one-pot synthesis of new pyrimido[1,6-a]thieno[2,3-d]pyrimidin-4-ones 3a,b is reported via base-catalyzed reaction of 2-amino-3-cyanothiophenes 1a,b with 2,4-dichloro-5-bromo-6-methylpyrimidine 2. Subsequent ...