Gene therapeutic research has been considered a risk based approach and faced many challenges in the past, as many ethical issues arose particularly after the first death caused by gene therapy in 1999. However, the journey ...

Cellular immortality happens upon impairment of cell-cycle checkpoint pathways(p53/p16/pRb), reactivation or up-regulation of telomerase enzyme, or upregulation of some oncogenes or oncoproteins leading to a higher rate ...