The molecular mechanisms underlying pluripotency

and lineage specification from embryonic stem cells

(ESCs) are largely unclear. Differentiation pathways

may be determined by the targeted activation of...

عملکرد هسته در سلولهای به میزان زیادی تحت تاثیر آرایش کروماتین و سازمان بندی محدوده های کروموزومی می باشد. جایگاه کروموزوم ها در داخل هسته، تشکیل لوپ های کروماتینی، تغییر در تراکم فیبرهای کروماتینی، و تشکیل و لوکالیزاسیون ...

An open chromatin architecture devoid of compact chromatin is thought to be associated with pluripotency in embryonic stem cells. Establishing this distinct epigenetic state may also be required for somatic cell reprogramming. However, there has...

of the nuclear landscape. We have used electron spectroscopic imaging (ESI) to visualize chromatin organization at the mesoscale level of resolution in both pluripotent and differentiated cell types. Pluripotent cells are characterized by a highly dispersed mesh...

Pluripotency is a central feature of stem and cancer cells. This feature enables cancer cells to self-renew and trans-differentiate. In this editorial, it is hypothesized that in cancer cells synchronized events rather than segmented procedures may...

Pluripotent stem cells (PSCs) have the potential to differentiate into many cell types and therefore can be a

valuable source for cell therapy. Embryonic stem cells (ESCs), which are derived from the inner cell mass (ICM...

Embryonal carcinoma (EC) cells, the stem cells of teratocarcinomas, are the malignant counterparts of pluripotent embryonic stem (ES)

cells, but commonly exhibit a reduced ability to differentiate, presumably because of continual selection...

Although a wealth of information currently exists for genetic networks involved in pluripotency of mouse embryonic stem cells mESCs, less is known about mouse embryonic germ cells (mEGCs). Especially To date more studies have focused almost...

Mammalian species utilize an inductive mechanism of germ cell specification, diverting the fate of some of somatic cells toward pluripotency and germ-cell totipotency. It is not known if avian species utilize a similar mechanism nor if, analogous...