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RISCompetition binding study of aspirin and amlodipine to humanserum albumin in multi-drug therapy: a molecular dynamic approach
The competition between drugs can be analyzed by molecular modeling and bioinformatics tools. The effect of the displacement of one drug from the complex of the other with human serum albumin
(HSA) has been described on the comparison...
Synthesis of new series of α-cyclodextrin esters as dopamine carrier molecule
A new series of amphiphilic α-cyclodextrins were synthesized by grafting N-acylated amino acids [valine, leucine, phenylalanine, methionine, and tryptophan (3a–e)] to the primary hydroxyl groups via ester bond formation. ...
ACE-Inhibitory and Antioxidant Activityof Temporin-Ra Peptide: Biochemical Characterization and Molecular Modeling Study
In this study, the inhibitory effect of Temporin-Ra (FP-14 peptide) on angiotensin converting enzyme(ACE) was evaluated. Inhibition mechanism was investi-gated by kinetic studies and molecular docking simulation.Lineweaver–Burk ...
Separate and simultaneous binding effects of aspirin and amlodipine to human serum albumin based on fluorescence spectroscopic and molecular modeling characterizations: A mechanistic insight for determining usage drugs doses
The bindi ng of asp irin (ASA) and amlo dipine (AML) to hu man serum albumin (HSA ) i n aqueou s solution was investiga ted by m ultiple te chnique s such as fluor escenc e que nching, resona nce lig ht scatteri ng (RLS), ...
Investigations with Spectroscopy, Zeta Potential and Molecular Modeling of the Non-Cooperative Behaviour Between Cyclophosphamide Hydrochloride and Aspirin upon Interaction with Human Serum Albumin: Binary and Ternary Systems from the View Point of Mul
The interaction between cyclophosphamide hydrochloride (CYC) and aspirin (ASA) with human serum albumin (HSA) was studied by various kind of spectroscopic, ζ potential and molecular modeling under physiological conditions. The fluorescence data...
Multi-spectroscopic and HPLC Studies of the Interaction Between Estradiol and Cyclophosphamide With Human Serum Albumin: Binary and Ternary Systems
albumin (HSA) under physiological conditions has been investigated by multi-spectroscopic in combination with molecular modeling techniques. Time-resolved and quenching fluorescence spectroscopies results revealed that the quenching of HSA fluorescence...
Spectroscopic and docking studies on the interaction between caseins and β- carotene
proteins. In this study, molecular interaction of caseins and β-carotene was analyzed using fluorescence, UV–Vis absorption, circular dichroism (CD), and computer-aided molecular modeling. Casein and its fractions were bound to β-carotene with a binding...
Synthesis of novel 3‑ substituted‑ 5H‑ benzo [5,6][1, 4] thiazino [3,2‑e][1,2,4] triazines and their 15‑ lipoxygenase inhibitory activity
A new group of 3-substituted-5H-benzo[5,6] [1,4]thiazino[3,2-e][1,2,4]triazines was designed, synthesized
and evaluated as inhibitors of 15-lipoxygenase (15-LO), and the results were compared with those of ...
Design and synthesis of a new series of amphiphilic peptide-β-cyclodextrins as phase transfer carriers for glucosamine
A new series of amphiphilic β-cyclodextrins were designed and synthesized by grafting peptide chains on to all primary hydroxyl groups via ester bond formation. The desired amphiphilic structures have been produced from ...
Investigation of the behavior of HSA upon binding to amlodipine and propranolol: Spectroscopic and molecular modeling approaches
molecular modeling technique. Fluorescence data suggest that amlodipine will quench the intrinsic fluorescence of HSA; whereas propranolol enhances the fluorescence of HSA. The binding constants for the interaction of amlodipine and propranolol with HSA were...