in mitochondrial function and production of free radicals. Adverse effects of elevated oxidative stress is a decrease in glutamate absorption that may cause increases in pain perception. Vitamin K2 is a fat-soluble vitamin, easily crosses the blood brain barrier...

the protective effects of vitamin K2 on toxicity induced by (Aβ) (1-42) and H2O2 in PC12 cells as an appropriate model of Alzheimer's cell damage. PC12 cells pretreated with vitamin K2 (5-200 μM) for 4, 24 and 48 h, and exposed to either Aβ (25 µM) for 48 h or H2...

Introduction . Vitamin K2 is a deriv ative of vitamin K. Effect o f vitamin K2 on the release and function of n eurotransmitters remain ed unknown; b ut du e to the effects of this substance in many neural processes, neu rod egen erative diseases (e...

Background and Aim:Menaquinone-4, a derivative of vitamin K is synthesized by intestinal bacteria and in many studies the presence of vitamin K2 (Menaquinone-4) with important functions in the brain at high concentrations has been demonstrated...

of vitamin K2 against toxicity and oxidative damage induced

by Aβ in PC12 cells as an appropriate model of Alzheimer's cell damage.

Methods : PC12 cells were pretreated with vitamin K2 (5, 10, 20, 50 µM) for 24h and then exposed

to Aβ...

Introduction: Neuropathic pain is a chronic pain caused by sensory neural system defects. This type of pain disrupts life because it is non-responsive to the common pain killers and takes a long time if repairs. Vitamin K2 by its antioxidant...

INTRODUCTON: Alzheimer disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive function. This study aimed to investigate the protective effect of vitamin K2 on toxicity and oxidative damage induced by H2O2 in PC...

Neuroprotection using compounds with dual functions of anti-apoptotic and antioxidant effects fight against neurodegeneration. Vitamin K2 acts as a cofactor in many biochemical pathways, including sphingolipid synthesis in the nervous system, which...