لطفا صفحه دو از فایل پیوست ملاحظه شود

لطفا صفحه دو از فایل پیوست ملاحظه گردد

Gene therapeutic research has been considered a risk based approach and faced many challenges in the past, as many ethical issues arose particularly after the first death caused by gene therapy in 1999. However, the journey of this research...

Introduction: Cancer remains the second cause of death in the world after coronary heart disease. Nowadays, most researchers have focused on specific cancer therapy, without adversely affecting other normal tissues. ...

Insulin-like growth factor gene (IGF-1) is one of the most important growth factors that plays a key role in the proliferation and differentiation of muscle cells. IGF-1 is also a radial stimulant in muscle hypertrophy in ...

Gene therapy involves the insertion of genes into the cells or tissues of individuals suffering from diseases and genetic disorders. Gene therapy can be classified into two main types, germ line gene therapy and somatic gene therapy. Although gene...

. Genome of lentivirus vectors (LVs) is integrated into the host cell genome and they accommodate a fair amount of foreign DNA. LVs are much less suitable for in vivo gene therapies due to their large diameter. Adenoviral vectors (AdVs) can be produced...

signal for expansion is required to obtain a therapeutic effect. Beside stem cells, other

therapeutic strategies such as gene therapy are being tested in patients and pre-clinical models. Since almost all types of

muscular dystrophies arise...

We have designed a keratinocyte-specific expression plasmid equipped with the K14-promoter by

inserting a 2240bp BglII/HindIII fragment, containing the upstream regulatory elements of the K14 gene, in a

digested ...

Ex vivo gene therapy requires a suitable bioreactor for production and delivery of

the gene products into a target tissue, and keratinocyte is suitable model in this regard

because of its potential for systemic release of proteins...