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RISEvaluating plasma expression of miR-21 in colorectal cancer patients in Khorasan population
Introduction: Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. Common methods used for CRC screening are invasive and it is necessary to develop novel effective and non-invasive methods for early diagnosis...
Downregulation of miR-21 in HEK293T cells and their conditioned medium in advancement of colorectal cancer treatment
Colorectal cancer as the second leading cause of cancer-related death with high prevalence have attracted scientists to unravel the secret of its underlying mechanisms. Although, novel therapeutics approaches like targeted therapy have shed...
Genes and SNPs Associated with Non-hereditary and Hereditary Colorectal Cancer
second leading cause of cancer-related deaths. The incidence of colorectal cancer has increased in Iran in
the past three decades and is now considered as a serious problem for our society. This cancer has two types hereditary and non...
Targeting the death receptor signaling pathway as a potential therapeutic target in the treatment of colorectal cancer
Despite advances in the diagnosis and treatment of colorectal cancer (CRC), it remains a major cause of cancer related death globally. There are currently no chemotherapeutic agents that have been found to eradicate the disease without adverse...
SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF
BACKGROUND: Thousands of long noncoding RNAs -lncRNAs- are aberrantly expressed in various types of cancers, however our understanding of their role in the disease is still very limited.
METHODS: We applied RNAseq ...
Variation in Blood and Colorectal Epithelia’s Key Trace Elements Along with Expression of Mismatch Repair Proteins from Localized and Metastatic Colorectal Cancer Patients
Colorectal cancer (CRC) is an increasingly common medical issue affecting millions worldwide, and contribution of the body’s
trace elements to CRC is arguable. The concentrations and buffered status of selenium, iron, copper, zinc, and phosphorus...
Investigating cytotoxic effects of baicalin on colorectal cancer cell lines C26 and CT26
Colorectal cancer (CRC) is one of the most common cancers worldwide. Despite significant progress has made in diagnosis and treatment strategies, CRC is still the 2nd major cause of cancer related deaths in the world. In the last decades, natural...
CRISPR/Cas9 targeting of SNHG15 as an oncogenic lncRNA inhibits cell proliferation capacity in colorectal cancer
Recently, thousands of long noncoding RNAs (lncRNAs) have been found to be aberrantly expressed in various types of cancers. Since colorectal cancer (CRC) is the third most common human malignancy worldwide, we investigated lncRNAs misregulated...
EZH2 Gene Silencing Can Affect the Expression of miR-155 and TP53INP1
Many genetic, epigenetic, and cellular studies on cancer are underway today, and the completion of the genetic and epigenetic library of cancer could be the way to treat the disease in the future. In this study, we have ...