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RISCo-Delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy
Development of drug resistance to anticancer drugs is an important challenge for cancer treatment. Recent studies focus on co-delivery of anticancer drugs and siRNA to overcome this challenge. Mesoporous silica nanoparticles ...
Synthesis of some novel 1,3,4-thiadiazine containing tetrazolonucleus
1,3,4-Thiadiazines represent the most widely studied class of compounds among the six
theoretically possible thiadiazine isomers; they are of interest in a chemical sense because they are labile compounds which are ...
Promising gene delivery system based on polyethylenimine-modified silica nanoparticles
This article reports on the synthesis and full characterization of innovative silica-based nanoparticle composed of fumed silica as a core decorated with polyethylenimine (PEI) with different molecular weights (25, 10 and ...
Synthesis of new (5-amino-1H-pyrazol-1-yl)(1H-pyrazol-1-yl)methanone derivatives
The chemistry of aminopyrazoles has been extensively investigated in the past [1]. The
considerable biological and medicinal activities of pyrazoles [2] and azolopyrazoles [3], for which
aminopyrazoles are ...
Co-delivery of Dual Toll-Like Receptor Agonists and Antigen in Poly(Lactic-Co-Glycolic) Acid/Polyethylenimine Cationic Hybrid Nanoparticles Promote Efficient In Vivo Immune Responses
Strategies to design delivery vehicles are critical in modern vaccine-adjuvant development.
Nanoparticles (NPs) encapsulating antigen(s) and adjuvant(s) are promising
vehicles to deliver antigen(s) and ...