Several derivatives of the novel benzo[b]pyrazolo[5′,1′:2,3]pyrimido[4,5-e][1,4]thiazine ring system have been synthesized through the one-pot cyclocondensation of 6-bromo-7-chloro-2-(ethylthio)5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (4...

H exchange inhibitors [3]. Due to the widespread biological activities of fused heterocyclic systems, in this study, we synthesized a novel benzo[b]pyrazolo[5\\',1\\':2,3]pyrimido[4,5­e][1,4]thiazine heterocyclic system. In our protocol, the desired compound...