Objectives: Experimental autoimmune encephalomyelitis (EAE) is an animal model of human CNS demyelinating

disease, multiple sclerosis (MS). This model is combined with inflammatory responses of the innate immune ...

Objectives: Multiple sclerosis is a neurodegenerative disease of CNS in which, inflammation causes the myelin to

disappear, ensuing disturbances in vision, speech, walking and memory. This overwhelming inflammatory ...

تا کنون روشهای مختلفی برای بررسی بیان پروتئینهای سلولی در روی سلولها، بافتها و یا عصاره پروتئینی آنها ابداع شده است. در این پژوهش، روشی جدید برای بررسی بیان پروتئینهای سلولی بر روی سلول های سالم در پلیت های کشت سلولی ارائه ...

The biological significance of protein aggregating diseases of the nervous system has considerably increased during the last decade. While knowing the human neurodegenerative disorders such as Alzheimer\\'s disease (AD), ...

شبکه اندوپلاسمیک (ER)، یکی از ارگانلهای داخل سلولی است که نقشی مرکزی در بالانس ذخایر کلسیم داخل سلولی، سیگنالینگ داخل سلولی، و همینطور کنترل فولدینگ پروتئینی مناسب در داخل سلول ایفا می کند. از اینرو، اختلال در کارکرد ER ...

Alzheimer\\\\\\\\\\\\\\'s disease is a neurodegenerative disorder characterized by slowly progressive dementia, with the hallmark of beta-amyloid peptides (Aβ) as the main constituent of the senile plaques. Aβ 1–42 is one ...

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) that mainly affects young adults, featuring gradual degeneration and loss of previously established functional myelin sheaths and, ...

Taranjabin manna (wet honey) has been used as a laxative, antipyretic, expectorant and to treat/prevent newborn jaundice. Groups of rats (n=7) were gavaged taranjabin manna or placebo (controls) and number, weight and water ...

Infection by the human immunodeficiency virus (HIV)

results in neurodegeneration caused by aberrant activation

of glial cells with ensuing neuronal death. Since

patients with HIV/AIDS often develop ...

Objective: Herein we investigated the neuropathogenic

outcomes and underlying mechanisms

of dual lentivirus infections with genetically distinct

viral strains as co-infections or super-infections.