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Fine-Tuning of the Cellular Signaling Pathways by Intracellular GTP Levels
It has become increasingly evident that among purine nucleotides, guanine based nucleotides specially guanosine-5´-triphosphate (GTP) serve as an important and independent regulatory factors for development and diverse ...
Acetone Extract of Almond Hulls Provides Protection against Oxidative Damage and Membrane Protein Degradation
Several studies have revealed that among foods, the consumption of edible nuts has
beneficial effects on health which are attributed to their high content of potent antioxidants.
Among nuts, the whole seed ...
Modulation of Oxidative Stress in Thrombin-Stimulated Platelets by Almond by-Product
Almond (Al) green hulls are waste materials that are generated annually in the almond harvest and recently gained much attention due to their antioxidant properties. However, paucity information is in literature relevant ...
3-Hydrogenkwadaphnine, a novel diterpene ester from Dendrostellera lessertii, its role in differentiation and apoptosis of KG1 cells
3-Hydrogenkwadaphnin (3-HK) (Fig. 1) is a daphnane-type diterpene ester isolated from the leaves of Dendrostellera lessertii (Thymelaeaceae) with differentiation and apoptotic potency among several leukemic cells without ...
Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin
Since differentiation-induction therapy represents an attractive strategy for treatment of a wide range of malignancies, universal efforts have been devoted to find new and potent differentiation inducers devoid of general ...
Differentiation and Apoptosis of U937 Leukemia Cells by an Active Compound from Dendrostellera lessertii
Background: Regarding the strong differentiation and anti-leukemic activity of Dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. The aim ...
Chemosensitization of human leukemia K562 cells to taxol by a Vanadium-salen complex
Vanadium complexes are a heterogeneous class of compounds exhibiting interesting biological properties.
Herein, we report the effect of a vanadium-salen complex (VO-salen) on proliferative behavior of K562 ...
Anti-proliferative and differentiation inducing activities of guanosine 5ˈ-triphosphate on osteosarcoma cell line
Among differentiating agents, purine bases and their corresponding nucleosides and nucleotides have been the center of focuses due to their important and diverse effects on many biological processes and also their physiological ...