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RISMesenchymal Stem Cell: A New Vehicle for Cancer Therapy
Introduction: Cancer remains the second cause of death in the world after coronary heart disease. Nowadays, most researchers have focused on specific cancer therapy, without adversely affecting other normal tissues. Mesenchymal stem cells (MSCs...
Simulation and Stability Assessment of Anti-EpCAM Immunotoxin for Cancer Therapy
Purpose: Epithelial cell adhesion molecule (EpCAM) is a dominant antigen in human colon
carcinoma tissue. Topology features of this antigen are different in normal and malignant
conditions; for instance, EpCAM ...
Targeting cancer stem cells by CD133 antigen
BACKGROUND: Cancer stem cells (CSCs), also known as tumour initiating cells, are highly
proliferating cancerous cells that have been found in several kinds of leukemia and solid tumours.
CSCs are likely to ...
Mesenchymal stem cells are a new efficiient candidate for cancer therapy
Cancer is one of the main causes of mortality and morbidity in all countries. Unfortunately, current conventional cancer therapies (such as surgery, chemotherapy and radiotherapy) are symptomatic and passive in nature. The absence of sufficient...
Bioinspired Nanonetworks for Targeted Cancer Drug Delivery
appropriate evaluation, we compare our work with a conventional chemotherapy approach using a mathematical model of cancer under actual experimental parameter settings. Simulation results show the merits of the proposed method in targeted cancer therapy...
Analysis of Chemokine Receptor Gene Expression in Esophageal Cancer Cells Compared with Breast Cancer with Insights into Metastasis
Background: Chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. In this study, the gene expression profile of some key chemokine receptors involved ...
CXCR4 and CCR7: Two eligible targets in targeted cancer therapy
Cancer is one of the most common cause of death in the world with high negative emotional, economic, and social impacts. Conventional therapeutic methods, including chemotherapy and radiotherapy, have not proven satisfactory ...
Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents
Theranostic nanoparticles have attracted considerable attention in recently revolutionized medicine.
Since the last decade, there has been a growing attempt to design various theranostic nanoparticles
but difficulties ...
pertubation of intracellular purine nucleotides balance as effective strategy for cancer therapy
It is entirely accepted that a metabolic change in purine nucleotide concentration occurs during carcinogenesis which facilitate the pathological process of malignant cells such as proliferation, invasion and metastasis. ...