INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTINOCICEPTIV EEFFECT OF TANACETUM PARTHENIUM
Year
: 2009
Abstract: Tanacetum parthenium (T.p.) is used in folk medicine as a treatment wiedly. We
reported the analgesic effect of T.p. flowers and leaves previously. This study was
designed to find how this mechanism is occurred by T.p. flower extract.
Based on our previous study, the dose of 50 mg/kg i.p. of the aqueous extract has
analgesic effect on mice (NMRI) (20 ± 2 g) that was used for study. We studied
involvement of the opioidergic, serotoninergic,α-adrenergic systems separatly in antinociceptive
effect. 15 min before the administration of the extract, animals were
pretreated with drugs, including naloxane (5mg/kg, i.p.), serotoninergic antagonist
cyproheptadine (4 mg/kg, i.p.) and α-adrenergic antagonist phentolamine (20mg/kg,
i.p.)(n > 6 in each group).
Pretreatment with naloxane increased pain percepation in the neurogenic phase of
formalin test compared to the control (p<0.001). Moreover cyproheptadine increased
the sensation of pain in both phases (p<0.05). Inhibition of α -adrenergic system was
not be able to attenuate the anti-nociceptive effect of the extract.
These results propose the involvement of sertoninergic and opioidergic systems in the
anti-nociceptive effect of the T.p. extract.
reported the analgesic effect of T.p. flowers and leaves previously. This study was
designed to find how this mechanism is occurred by T.p. flower extract.
Based on our previous study, the dose of 50 mg/kg i.p. of the aqueous extract has
analgesic effect on mice (NMRI) (20 ± 2 g) that was used for study. We studied
involvement of the opioidergic, serotoninergic,α-adrenergic systems separatly in antinociceptive
effect. 15 min before the administration of the extract, animals were
pretreated with drugs, including naloxane (5mg/kg, i.p.), serotoninergic antagonist
cyproheptadine (4 mg/kg, i.p.) and α-adrenergic antagonist phentolamine (20mg/kg,
i.p.)(n > 6 in each group).
Pretreatment with naloxane increased pain percepation in the neurogenic phase of
formalin test compared to the control (p<0.001). Moreover cyproheptadine increased
the sensation of pain in both phases (p<0.05). Inhibition of α -adrenergic system was
not be able to attenuate the anti-nociceptive effect of the extract.
These results propose the involvement of sertoninergic and opioidergic systems in the
anti-nociceptive effect of the T.p. extract.
Keyword(s): Tanacetum parthenium,opioidergic system,sertoninergic system,formalin test
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INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTINOCICEPTIV EEFFECT OF TANACETUM PARTHENIUM
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| contributor author | مسعود فریدونی | en |
| contributor author | Leila Etemadi | en |
| contributor author | Masoud Fereidoni | fa |
| date accessioned | 2020-06-06T14:00:21Z | |
| date available | 2020-06-06T14:00:21Z | |
| date copyright | 7/27/2009 | |
| date issued | 2009 | |
| identifier uri | http://libsearch.um.ac.ir:80/fum/handle/fum/3378478?locale-attribute=en | |
| description abstract | Tanacetum parthenium (T.p.) is used in folk medicine as a treatment wiedly. We reported the analgesic effect of T.p. flowers and leaves previously. This study was designed to find how this mechanism is occurred by T.p. flower extract. Based on our previous study, the dose of 50 mg/kg i.p. of the aqueous extract has analgesic effect on mice (NMRI) (20 ± 2 g) that was used for study. We studied involvement of the opioidergic, serotoninergic,α-adrenergic systems separatly in antinociceptive effect. 15 min before the administration of the extract, animals were pretreated with drugs, including naloxane (5mg/kg, i.p.), serotoninergic antagonist cyproheptadine (4 mg/kg, i.p.) and α-adrenergic antagonist phentolamine (20mg/kg, i.p.)(n > 6 in each group). Pretreatment with naloxane increased pain percepation in the neurogenic phase of formalin test compared to the control (p<0.001). Moreover cyproheptadine increased the sensation of pain in both phases (p<0.05). Inhibition of α -adrenergic system was not be able to attenuate the anti-nociceptive effect of the extract. These results propose the involvement of sertoninergic and opioidergic systems in the anti-nociceptive effect of the T.p. extract. | en |
| language | English | |
| title | INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTINOCICEPTIV EEFFECT OF TANACETUM PARTHENIUM | en |
| type | Conference Paper | |
| contenttype | External Fulltext | |
| subject keywords | Tanacetum parthenium | en |
| subject keywords | opioidergic system | en |
| subject keywords | sertoninergic system | en |
| subject keywords | formalin test | en |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1019777.html | |
| conference title | XXXVI th International Union of Physiological Sciences (IUPS | en |
| conference location | کیوتو | fa |
| identifier articleid | 1019777 |