Studies on interaction between propranolol and HSA in presence and absence of magnetic field
Author:
, , ,Year
: 2010
Abstract: Human serum albumin (HSA) is the most abundant carrier protein of
the blood with a high affinity for a wide range of metabolites and drugs
and have many physiological functions. Propranolol, 1-[isopropylamino-
3-[1-naphthyloxy]-2-propanol], is a adrenoceptor antagonist (-blocker),
which is widely used in the treatment of several diseases such as
cardiac arrhythmia, angina pectoris, sinus tachycardia, thyrotoxicosis,
hypertrophic subaortic stenosis and hypertension. The effects of static
magnetic fields (SMFs) on biological systems have been a topic of
considerable interest for last two decades. The increasing production of
electric (EMFs) and magnetic fields (MFs) due to the increasing use of
electronic devices in homes and work places, is encouraging studies on
the influences of magnetic fields on living organisms with a goal to
protect better human health against their probable unfavorable effects.
In this paper, the interaction between propranolol HSA and in
physiological buffer (pH 7.4) was investigated by UV and fluorescence
absorption spectroscopy. In order to understand the effect of magnetic
field, all experiments were also done in the presence of magnetic field
(3 mT); and the binding parameters were determined for both cases.
The Hill equation was employed to analyze the data obtained, for
determining of the binding capacity, g, binding constant, K, and Hill
constant, nH,.
The results showed that the values of g and nH increased slightly
in the presence of magnetic field, and the binding constant in both
method, uv and fluorescence spectroscopy, was decreased in the
magnetic field exposed situation.
the blood with a high affinity for a wide range of metabolites and drugs
and have many physiological functions. Propranolol, 1-[isopropylamino-
3-[1-naphthyloxy]-2-propanol], is a adrenoceptor antagonist (-blocker),
which is widely used in the treatment of several diseases such as
cardiac arrhythmia, angina pectoris, sinus tachycardia, thyrotoxicosis,
hypertrophic subaortic stenosis and hypertension. The effects of static
magnetic fields (SMFs) on biological systems have been a topic of
considerable interest for last two decades. The increasing production of
electric (EMFs) and magnetic fields (MFs) due to the increasing use of
electronic devices in homes and work places, is encouraging studies on
the influences of magnetic fields on living organisms with a goal to
protect better human health against their probable unfavorable effects.
In this paper, the interaction between propranolol HSA and in
physiological buffer (pH 7.4) was investigated by UV and fluorescence
absorption spectroscopy. In order to understand the effect of magnetic
field, all experiments were also done in the presence of magnetic field
(3 mT); and the binding parameters were determined for both cases.
The Hill equation was employed to analyze the data obtained, for
determining of the binding capacity, g, binding constant, K, and Hill
constant, nH,.
The results showed that the values of g and nH increased slightly
in the presence of magnetic field, and the binding constant in both
method, uv and fluorescence spectroscopy, was decreased in the
magnetic field exposed situation.
Keyword(s): propranolol,HSA,magnetic field
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Studies on interaction between propranolol and HSA in presence and absence of magnetic field
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| contributor author | زینب روح بخش زائری | en |
| contributor author | محمدرضا حسین دخت | en |
| contributor author | Zeinab Rouhbakhsh zaeri | fa |
| contributor author | Mohammad Reza Housaindokht | fa |
| date accessioned | 2020-06-06T13:56:55Z | |
| date available | 2020-06-06T13:56:55Z | |
| date copyright | 2/24/2010 | |
| date issued | 2010 | |
| identifier uri | http://libsearch.um.ac.ir:80/fum/handle/fum/3375994?locale-attribute=en | |
| description abstract | Human serum albumin (HSA) is the most abundant carrier protein of the blood with a high affinity for a wide range of metabolites and drugs and have many physiological functions. Propranolol, 1-[isopropylamino- 3-[1-naphthyloxy]-2-propanol], is a adrenoceptor antagonist (-blocker), which is widely used in the treatment of several diseases such as cardiac arrhythmia, angina pectoris, sinus tachycardia, thyrotoxicosis, hypertrophic subaortic stenosis and hypertension. The effects of static magnetic fields (SMFs) on biological systems have been a topic of considerable interest for last two decades. The increasing production of electric (EMFs) and magnetic fields (MFs) due to the increasing use of electronic devices in homes and work places, is encouraging studies on the influences of magnetic fields on living organisms with a goal to protect better human health against their probable unfavorable effects. In this paper, the interaction between propranolol HSA and in physiological buffer (pH 7.4) was investigated by UV and fluorescence absorption spectroscopy. In order to understand the effect of magnetic field, all experiments were also done in the presence of magnetic field (3 mT); and the binding parameters were determined for both cases. The Hill equation was employed to analyze the data obtained, for determining of the binding capacity, g, binding constant, K, and Hill constant, nH,. The results showed that the values of g and nH increased slightly in the presence of magnetic field, and the binding constant in both method, uv and fluorescence spectroscopy, was decreased in the magnetic field exposed situation. | en |
| language | English | |
| title | Studies on interaction between propranolol and HSA in presence and absence of magnetic field | en |
| type | Conference Paper | |
| contenttype | External Fulltext | |
| subject keywords | propranolol | en |
| subject keywords | HSA | en |
| subject keywords | magnetic field | en |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1014936.html | |
| conference title | نهمین همایش بیوشیمی فیزیک ایران | fa |
| identifier articleid | 1014936 |