Effects of topical allicin on second-intention wound healing in dogs-histological aspects

Author:
, , , , , , , ,
Year
: 2006
Abstract: Abstract Alllicin is one of the pharmacologically active

garlic sulfur compounds that have antimicrobial (antibacte-

rial, antiviral, antifungal and antiparasitic) and vasodilating

effects. Five normal, male, mixed-breed dogs were selected

to investigate the effects of allicin (5 mg/ml in methyl

cellulose gel) as a topical treatment for full-thickness,

excisional wounds. The dogs were approximately 3 years

old. The histological aspects of second-intention wound

healing were studied. Eight full-thickness skin wounds

(20×20 mm) were created on the back of each dog. On

days 0, 7, 14 and 21, each dog received two wounds,

symmetrically, and were assigned to one of two groups:

control (methyl cellulose gel) or test (allicin 5 mg/ml methyl

cellulose gel). Wounds were treated once daily for a week.

Left-side wounds were treated with allicfin (test group) and

right-side wounds were treated with methylcellulose gel

(control group). At day 28 (4 weeks) after initial wounding,

biopsies were taken from wounds for histological examina-

tion. The density of inflammatory cells in the center of the

day 7 wounds was significantly lower in test group

(P=0.041), but the density of fibrocytes and fibroblasts in

the center of day 7 wounds was significantly higher in the

test group (P=0.042). No significant differences were

observed in the amount of collagen and fibrin between the

test and control wounds (P>0.05).
Keyword(s): Allicin,Healing,Dog
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