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In this study artificially synthesized siRNAs targeting a-actinin were used to determine

whether TV has a functional RNAi system that could potentially be exploited in genetic

functional analyses and therapeutic approaches. For this purpose, TV...

is not functional in all orders of life. Here, by using synthetic siRNAs targeting two genes, i.e. a-actinin and cystein protease 12 (cp12), we demonstrate T. vaginalis cells are amenable to RNAi experiments conducted by extrinsic siRNAs. Electroporation of si...