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RISGenomic and nongenomic effects of intrahippocampal microinjection of testosterone on long-term memory in male adult rats.
, was assessed in one of the fundamental centers of learning and memory, the hippocampus, on long-term memory (LTM) in passive avoidance conditioning. Different doses of testosterone enanthate (T) or testosterone-BSA (T-BSA) bilaterally were injected into the CA1...
A comparative study on the effects of type I and type II diabetes on learning and memory deficit and hippocampal neuronal loss in rat
Aim: In addition to learning and memory impairments, diabetes may also brings about neuronal loss in different regions of the brain specially hippocampus. In this line, the present study was conducted to investigate the effects of type I (T1D...
Study of Cognitive Deficit and Hippocampal Neuronal Loss in Type 1 and Type 2 Diabetic Models
In addition to cognitive deficit, diabetes may also causes neuronal loss in different areas of the brain specially hippocampus. The aim of the present study was to investigate the effects of type I (T1D) and type II (T2D) diabetes on cognitive...
Effects of infantile acute repeated hyperglycemia on neuronal density of hippocampus and severity of PTZ induced convulsions in Wistar rats
Purpose: Hyperglycemia and metabolic disturbances may induce morphological and behavioral changes in some neuronal structures such as hippocampus. The aim of our study was to investigate the effects of infantile repeated acute hyperglycemia...
Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol
nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated....
Protective effects of Nesfatin-1 peptide on cerebral ischemia reperfusion injury via inhibition of neuronal cell death and enhancement of antioxidant defenses
of hippocampus in rats. 56 male Wistar rats (240-270 g) were randomly selected and allocated into four groups: (1) sham, (2) nesfatin-1, (3) ischemia/reperfusion, (4) ischemia/reperfusion+nesfatin-1. Cerebral ischemia induced by the occlusion of the common...
Comparison between the effects of type 1 and type 2 diabetes on hippocampal neuronal density in Wistar rats
Background: Diabetes is one of metabolic disorders characterized by hyperglycemia due to defects
in insulin secretion, insulin function, or both. Diabetes induces neuronal death in different regions
of the brain especially hippocampus...
A transient insulin system dysfunction in newborn rat brain followed by neonatal intracerebroventricular administration of streptozotocin could be accompanied by a labile cognitive impairment
The early postnatal period is a critical period of hippocampus development, which is highly dependent on insulin receptor (IR) signaling and very important in cognitive function. The present study was conducted in order to present a model...
Effect of frequent infantile Sodium Thiopental administration on GAD65 gene expression in 1.5 month old male wistar rats
was to investigate the effect of repeated Thiopental administration in infancy on mRNA expression
of GAD65 at 1.5 month after the birth in hippocampus of rats.
Materials and Methods. Eight 4-day old male Wistar rats were divided in two groups as control...
Effect of repeated infancy anesthesia induced by Sodium Thiopental on GAD65 gene expression before maturation in Hippocampus of male Wistar rats
terminals. The aim of this study was to investigate the effect of repeated
Thiopental administration in infancy on mRNA expression of GAD65 in hippocampus.
Materials and Methods. 4-day old male Wistar rats was divided in two groups as control...