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RISSynthesis and DFT study on Hantzsch reaction to produce asymmetrical compounds of 1,4-dihydropyridine derivatives for P-glycoprotein inhibition as anticancer agent
سال: 2018
خلاصه:
BACKGROUND:
P-glycoprotein (P-gp) causes the efflux of cancer chemotherapy drugs from tumor cells, so its inhibition can be one target for designing and synthesis of new anticancer drugs.
OBJECTIVE:
In ...
H5BW12O40-Catalyzed syntheses of 1,4-dihydropyridines and polyhydroquinolines via Hantzsch reaction: Joint experimental and computational studies
سال: 2020
خلاصه:
A series of polyhydroquinoline derivatives were effectively synthesized via Hantzsch reaction in high yields in the presence of catalytic amounts of a highly negatively charged borotungstic acid H5BW12O40 in refluxing EtOH under green and mild...
A Nano-sized Nd–Ag@polyoxometalate Catalyst for Catalyzing the Multicomponent Hantzsch and Biginelli Reactions
سال: 2020
خلاصه:
For the first time the catalytic activity of AgNdSiW11, was examined in two named reactions,
namely Hantzsch and Biginelli reactions. A simple, eco-friendly and highly efficient one-pot
synthesis of polyhydroquinoline ...