Effect of substitution on the intramolecular hydrogen bonding of 4-amino-3-penten-2-one: Ab initio,

In summary, new bis-pyrimidine derivatives (4a-g) were prepared in a three-step procedure based on 5-bromo-2,4-dichloro-6-methylpyrimidine (1) as starting material. In spite of our expectation based on our previous studies, ...

we have presented an efficient synthetic pathway for the synthesis of new derivatives of imidazo[2ˈ,1ˈ:2,3] thiazolo[5,4-d]pyrimidin 4(a-g) via the heterocyclization of 2,5-dichloro-7-methylthiazolo[5,4-d]pyrimidine (1) ...