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RISProtective effect of Crocin on Aβ1-42 –induced neurotoxicity in primary rat basal forebrain neurons
Objectives: Crocin, an active constituent of saffron (Crocus sativus L.) has widely been known for its antioxidant
properties, which nominate this herbal compound to be of therapeutic value in the neurodegenerative disorders...
Neuroinflammation and Endoplasmic Reticulum Stress Are Coregulated by Crocin To Prevent Demyelination and Neurodegeneration
plasmid, XBP-1/s, BiP, and NOS2 were induced,
which was suppressed by crocin treatment (p , 0.05). Crocin also protected oligodendrocytes exposed to cytotoxic supernatants
derived from Syncytin-1–expressing astrocytes (p , 0.05) and NO...
Crocin suppresses the expression of iNOS in spinal cords of Experimental Autoimmune Encephalitis in mice as a model of Human Multiple Sclerosis
pathogenesis of multiple sclerosis. Saffron extract or its active constituent, crocin, have been shown to pose potential
therapeutic effects in different models of oxidative stress-induced neurodegenerative disorders.
Materials & Methods: Herein...
Evaluation of the effects of saffron–cumin intercropping ratios on quality and yield under semi-arid conditions
Medicinal and aromatic plants are looked upon not only as a source of affordable health care products but also as a source of income. As demand for organic products is increasing rapidly in the world market, adoption of ...
Evaluation of the effects of saffron–cumin intercropping on growth,quality and land equivalent ratio under semi-arid conditions
as the first and the second experimental factors, respectively.Based on the results, interaction between saffron planting density and saffron–cumin ratio was significanton flower number and dried stigma yield. However, crocin, picrocrocin and safranal were...
Nonlinear Optical Properties of Crocin: From Bulk Solvent to Nano-confined Droplet
Crocin has a strong Two-photon Absorption (TPA) capability that makes it suitable for medicine and photonic devices. To study the linear and nonlinear optical properties of crocin in solvent and Microemulsion (MEs), Z-scan instruments, Uv...
Molecular Dynamics Simulation of Crocin and Dimethylcrocetin Interactions with DNA
In this work, the interactions of the crocin and dimethylcrocetin (DMC) as anti-cancer drugs with a Dickerson DNA was investigated. Molecular dynamic simulations of Crocin, DMC and DNA composed of twelve base pairs and a sequence of the d...
Effects of Different Water Supply and Corm Planting Density on Crocin, Picrocrocin and Safranal, Nitrogen Uptake and Water Use Efficiency of Saffron Grown in Semi-Arid Region
Saffron’s color, taste and odor result from the chemicals crocin, picrocrocin and safranal, respectively. Hence, in addition to quantitative yield, secondary metabolites content are known as crucial factors for a successful saffron production...