Immunotoxin (IT) therapy is promising approach for targeted cancer therapy with the minimal side

effects. These types of drugs are chimeric proteins with two main parts including death and ligand

domains. Accordingly, structural...

Breast cancer is the leading cause of cancer-related death among females worldwide. Globally, more than 1.1 million females are diagnosed each year, representing around 10% of all newly diagnosed cancer cases. The mortality rate for premenopausal...

identifying and targeting cancer stem cells are one of the main causes metastasis...

Cancer includes more than hundred diseases which arise from unlimited replication of mutated

cells with the potential to invade to other parts of the body. Current research in this field is mainly

focusing on carcinogenesis, early...

protein synthesis and induce apoptosis, thus RNase could

be considered as a potential candidate for cancer chemotherapeutic. Ribonuclease inhibitor (RI) is a

cytosolic protein that binds to pancreatic-type ribonucleases with femtomolar...

Hydroxyapatite is a calcium phosphate with the formula Ca10(PO4)6(OH)10 and it is the main

constituent of mineral phase of bone. This biomaterial is widely used after bone tumor surgery for

treatment of bone ...

investigated in esophageal and breast cancer cell lines.

Methods: In a descriptive study, gene expression profile of CCR1, CCR6, CCR7, CCR9, CXCR1, and CXCR4 in human esophageal cancer cell line (KYSE-30) and human breast cancer cell line (MCF7) were...

Cancer stem cells (CSCs) are a minor subset of chemotherapy-resistant and radiotherapy-resistant

tumor cells that can undergo unlimited self-renewal and generate tumor mass. CSC-targeted therapies

are more effective therapeutic...

BACKGROUND: Cancer stem cells (CSCs), also known as tumour initiating cells, are highly

proliferating cancerous cells that have been found in several kinds of leukemia and solid tumours.

CSCs are likely to share many of the properties...

has effects on secretion of some hormons related to adipokines. Adiponectin is an adipokine having an opposite relationship with insulin resistance and breast cancer. It is also the connection between breast cancer incidence and obesity. Adiponectin...