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RISIn-silico evidences of regulatory roles of WT1 transcription factor binding sites on the intervening sequences of the human Bcl-2 gene
.
Objective and Method: Accordingly, the intron 2 (In-2) of the human B-cell lymphoma 2 (hBcl2) gene, with regard to the size of the In-2 as well as critical roles of the gene in the homeostatic of the cellular balance, was analyzed by using in-silico approaches...
Paternal breed effects on expression of IGF-II, BAK1 and BCL2-L1 in bovine preimplantation embryos
-related genes BAK1 and BCL2-
L1 in in vitro produced (IVP) bovine embryos derived from two unrelated paternal breeds (Holstein
and Brown Swiss). The degree of correlation of IGF-II expression pattern with embryo developmental...
Co-Delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy
(BCL-2) siRNA. The in vitro cytotoxicity and in vivo efficacy of different formulations were evaluated. Mean size of MSNs ranged from 98 to 247 nm. EPI release from MSNs was pH-dependent. MSNs loaded with EPI and siRNA showed better in vitro...
The discovery of possible regulatory regions inside the intron 2 of human Bcl-2 gene
and differentiated cells in most adult tissues and
cancer. These processes are controlled via complicated processes by a variety of cis and trans
acting regulatory elements (REs). Among these controllers, Bcl-2 family consists of a set of trans...