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Synthesis and DFT study on Hantzsch reaction to produce asymmetrical compounds of 1,4-dihydropyridine derivatives for P-glycoprotein inhibition as anticancer agent
Year: 2018
Abstract:
compounds of 1,4-dihydropyridine (DHP) were recommended as inhibitors of P-gp.
METHODS:
We synthesized new symmetrical DHP with 36% - 43% yield by the reaction of new reactants. In biological studies, these compounds have high...
H5BW12O40-Catalyzed syntheses of 1,4-dihydropyridines and polyhydroquinolines via Hantzsch reaction: Joint experimental and computational studies
Year: 2020
Abstract:
A series of polyhydroquinoline derivatives were effectively synthesized via Hantzsch reaction in high yields in the presence of catalytic amounts of a highly negatively charged borotungstic acid H5BW12O40 in refluxing EtOH ...