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Beneficial effects of allicin on lead induced tissue enzyme alterations in common carp (Cyprinus carpio)

نویسنده:
حسن باغیشنی
,
داور شاهسونی
,
Hasan Baghishani
,
Davar Shahsavani
سال
: 2011
چکیده: Introduction: In toxicological studies, the alterations in the

enzymatic activities directly reflect the metabolic disturbances and

cell damage in specific organs. The aim of the current study was to

determine the effects of lead exposure on tissue enzyme activities of

aspartate aminotransferase (AST), alanine aminotransferase (ALT),

alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in

selected tissues of common carp and also to evaluate the beneficial

effects of allicin, the main active constituent of garlic, on modulating

enzyme alterations.

Methods: Common carp (Cyprinus carpio; total, n=60) were

divided randomly into three groups of 20 each. Group I fish were

reared in normal freshwater and served as the control. Group II fish

were exposed to lead acetate (7.0 mg L−1) for 10 days. Group III fish

were exposed to lead acetate (7.0 mg L−1) for 10 days and also

received dietary allicin (10 mg/kg body weight, daily) during lead

acetate treatment. At the end of each exposure, enzyme activities in

prepared tissue homogenates were determined using colorimetric

methods.

Results: Lead exposure caused a significant elevation of AST, ALT

and LDH in the liver, as compared to control group (P<0.05). The

AST, ALT, ALP and LDH levels in kidney homogenates were

considerably increased following lead exposure, although these

increases were only significant for ALT and ALP values. Significant

increases of brain ALT and gill ALP activities were also observed

following lead exposure. However, alterations in the activities of

other measured enzymes in both brain and gill of experimental

groups were not significant.

Conclusion: Allicin supplementation was effective in attenuating

the increase in Pb-induced tissue enzyme activities in the most

organs; therefore it might have some protective and therapeutic

effects on lead poisoning. However, much more extensive biochemical

and toxicological research are needed for better understanding of

the molecular basis of lead induced tissue enzyme alterations and

ameliorative properties of allicin.
یو آر آی: http://libsearch.um.ac.ir:80/fum/handle/fum/3380211
کلیدواژه(گان): Lead poisoning,Allicin,Tissue enzyme activity,Common

carp
کالکشن :
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    Beneficial effects of allicin on lead induced tissue enzyme alterations in common carp (Cyprinus carpio)

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contributor authorحسن باغیشنیen
contributor authorداور شاهسونیen
contributor authorHasan Baghishanifa
contributor authorDavar Shahsavanifa
date accessioned2020-06-06T14:02:52Z
date available2020-06-06T14:02:52Z
date copyright9/6/2011
date issued2011
identifier urihttp://libsearch.um.ac.ir:80/fum/handle/fum/3380211
description abstractIntroduction: In toxicological studies, the alterations in the

enzymatic activities directly reflect the metabolic disturbances and

cell damage in specific organs. The aim of the current study was to

determine the effects of lead exposure on tissue enzyme activities of

aspartate aminotransferase (AST), alanine aminotransferase (ALT),

alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in

selected tissues of common carp and also to evaluate the beneficial

effects of allicin, the main active constituent of garlic, on modulating

enzyme alterations.

Methods: Common carp (Cyprinus carpio; total, n=60) were

divided randomly into three groups of 20 each. Group I fish were

reared in normal freshwater and served as the control. Group II fish

were exposed to lead acetate (7.0 mg L−1) for 10 days. Group III fish

were exposed to lead acetate (7.0 mg L−1) for 10 days and also

received dietary allicin (10 mg/kg body weight, daily) during lead

acetate treatment. At the end of each exposure, enzyme activities in

prepared tissue homogenates were determined using colorimetric

methods.

Results: Lead exposure caused a significant elevation of AST, ALT

and LDH in the liver, as compared to control group (P<0.05). The

AST, ALT, ALP and LDH levels in kidney homogenates were

considerably increased following lead exposure, although these

increases were only significant for ALT and ALP values. Significant

increases of brain ALT and gill ALP activities were also observed

following lead exposure. However, alterations in the activities of

other measured enzymes in both brain and gill of experimental

groups were not significant.

Conclusion: Allicin supplementation was effective in attenuating

the increase in Pb-induced tissue enzyme activities in the most

organs; therefore it might have some protective and therapeutic

effects on lead poisoning. However, much more extensive biochemical

and toxicological research are needed for better understanding of

the molecular basis of lead induced tissue enzyme alterations and

ameliorative properties of allicin.
en
languageEnglish
titleBeneficial effects of allicin on lead induced tissue enzyme alterations in common carp (Cyprinus carpio)en
typeConference Paper
contenttypeExternal Fulltext
subject keywordsLead poisoningen
subject keywordsAllicinen
subject keywordsTissue enzyme activityen
subject keywordsCommon

carp
en
identifier linkhttps://profdoc.um.ac.ir/paper-abstract-1023421.html
conference title12th Iranian Congress of Biochemistry & 4th International Congress of Biochemistry & Molecular Biologyen
conference locationمشهدfa
identifier articleid1023421
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