Non-Newtonian effects of blood on LDL transport inside the arterial lumen and across multi-layered arterial wall with and without stenosis

نویسنده:
, , , , , ,
سال
: 2016
چکیده: Blood non-Newtonian behavior on low-density lipoproteins (LDL) accumulation is analyzed

numerically, while fluid-multilayered arteries are adopted for nonstenotic and 30%–60% symmetrical

stenosed models. Present model considers non-Newtonian effects inside the lumen and

within arterial layers simultaneously, which has not been examined in previous studies. Navier–

Stokes equations are solved along with the mass transport convection–diffusion equations and

Darcy's model for species transport inside the luminal flow and across wall layers, respectively.

Carreau model for the luminal flow and the modified Darcy equation for the power-law fluid

within arterial layers are employed to model blood rheological characteristics, appropriately.

Results indicate that in large arteries with relatively high Reynolds number Newtonian model

estimates LDL concentration patterns well enough, however, this model seriously incompetent

for regions with low WSS. Moreover, Newtonian model for plasma underestimates LDL concentration

especially on luminal surface and across arterial wall. Therefore, applying non-Newtonian

model seems essential for reaching to a more accurate estimation of LDL distribution

in the artery. Finally, blood °ow inside constricted arteries demonstrates that LDL concentration

patterns along the stenoses inside the luminal °ow and across arterial layers are strongly

in°uenced as compared to the nonstenotic arteries. Additionally, among four stenosis severity

grades, 40% stenosis is prone to more LDL accumulation along the post-stenotic regions.
کلیدواژه(گان): Fluid-multilayered artery,low-density lipoprotein,non-Newtonian fuid,stenosis
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