The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics

Abstract

Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This<br><br>kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding<br><br>to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used<br><br>as experimental subjects.<br><br>Methods: For EEG study, electrodes were inserted into the cortex of animals according to<br><br>paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their<br><br>SWDs were compared with each others.<br><br>Results: Findings showed a significant increase in the mean number of seizures during<br><br>recording period. But the mean number of SWDs during seizures did not show any significant<br><br>differences between groups.<br><br>Discussion: These results may be due to involvement of GABA antagonistic effects of FQs<br><br>and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine<br><br>physiopathology of SWDs and find new effective substance against this kind of epilepsy.