The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics
Author:
, , , , , ,Year
: 2013
Abstract: Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This
kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding
to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used
as experimental subjects.
Methods: For EEG study, electrodes were inserted into the cortex of animals according to
paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their
SWDs were compared with each others.
Results: Findings showed a significant increase in the mean number of seizures during
recording period. But the mean number of SWDs during seizures did not show any significant
differences between groups.
Discussion: These results may be due to involvement of GABA antagonistic effects of FQs
and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine
physiopathology of SWDs and find new effective substance against this kind of epilepsy.
kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding
to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used
as experimental subjects.
Methods: For EEG study, electrodes were inserted into the cortex of animals according to
paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their
SWDs were compared with each others.
Results: Findings showed a significant increase in the mean number of seizures during
recording period. But the mean number of SWDs during seizures did not show any significant
differences between groups.
Discussion: These results may be due to involvement of GABA antagonistic effects of FQs
and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine
physiopathology of SWDs and find new effective substance against this kind of epilepsy.
Keyword(s): Ciprofloxacin,
Absence Epilepsy,
Wag/Rij,
EEG
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The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics
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| contributor author | علی مقیمی | en |
| contributor author | Samaneh Mollazadeh | en |
| contributor author | فاطمه بهنام رسولی | en |
| contributor author | Reza Shiee | en |
| contributor author | Mohammad Ali Khalilzade | en |
| contributor author | Ali Moghimi | fa |
| contributor author | Fatemeh Behnam Rassouli | fa |
| date accessioned | 2020-06-06T13:11:45Z | |
| date available | 2020-06-06T13:11:45Z | |
| date issued | 2013 | |
| identifier uri | http://libsearch.um.ac.ir:80/fum/handle/fum/3345416 | |
| description abstract | Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy. | en |
| language | English | |
| title | The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat s Electroencephalogram Characteristics | en |
| type | Journal Paper | |
| contenttype | External Fulltext | |
| subject keywords | Ciprofloxacin | en |
| subject keywords | Absence Epilepsy | en |
| subject keywords | Wag/Rij | en |
| subject keywords | EEG | en |
| journal title | Basic and Clinical Neuroscience | fa |
| pages | 31-35 | |
| journal volume | 4 | |
| journal issue | 1 | |
| identifier link | https://profdoc.um.ac.ir/paper-abstract-1033059.html | |
| identifier articleid | 1033059 |