A new series of 3-methyl-6-[1-(pyrimidin-4-yl)ethyl]-5H-pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives was synthesised through the condensation reaction of 5-bromo-4-[1-(5-bromo-2,6-dichloropyrimidin ...

A new one-pot multicomponent reaction of equimolar amounts of malononitrile and benzaldehyde in ethanol for the synthesis of hexahydropyrido[2,3-d]pyrimidine derivatives through a sequence of Knoevenagel condensation, ...

Introduction: Pyrimidine nucleus has played crucial role in the history of heterocyclic chemistry and has been used extensively as important pharmacophor and synthon in the field of organic chemistry and drug design. ...

Development of straightforward and efficient methods for rapid construction of nitrogen and sulfur-containing heterocyclic compounds is an important target in synthetic, medicinal chemistry and in drug design.1 For instance, ...

Pyrimidothiazines are a class of heterocyclic compounds that have been described as corrosion inhibitor for carbon steel in 1.0 M HCl, Filament temperature sensitive protein Z (FtsZ) inhibitors, 15-LO inhibitory activities, ...

Several derivatives of the novel tricyclic system ‘dipyrimido[2,1-
b:4,5-d][1,3]thiazine’ were synthesized via inter- and intramolecular heterocyclization of 2,4-dichloro-5--chloromethyl--6-methylpyrimidine and ...