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RISThe use of siRNA technology for the identification of differentially expressed genes in DMD: possible targets for gene thepray
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Molecular Pathology of DMD
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Developmemnt of RNAi technique to Study DMD Molecular pathology
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Potent RNAi-mediated dystrophin knockdown in skeletal muscle cells in vitro and in vivo
Duchenne muscular dystrophy (DMD) is a common inheritable human disease, caused by mutations in the dystrophin gene, the longest known human gene (~2.5Mb long), located on the short arm of X chromosome. DMD is clinically ...
The use of siRNA technology for identification of differentially expressed genes in Duchenne Muscular Dystrophy: Possible targets for gene therapy
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Potent Dystrophin Knockdown in vitro and in vivo using RNAi Technology and Expression Signature of Myotubes with dystrophin Knocked down
Duchenne Muscular Dystrophy (DMD) is one of a group of genetically heterogeneous muscular dystrophies that are characterized by progressive weakness and wasting of skeletal muscle. Loss of myofibres occurs in response to ...
Potent Dystrophin Knockdown in vitro and in vivo and transcriptomic evaluation of dystrophin deficiency
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Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disorder caused by mutations in the dystrophin gene. DMD has a complex and as yet incompletely defined molecular pathophysiology hindering development ...