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RISStructural And Functional Optimization Of SS1P Based On In- Silico Simulation
Immunotoxin (IT) therapy is promising approach for targeted cancer therapy with the minimal side
effects. These types of drugs are chimeric proteins with two main parts including death and ligand
domains. ...
Structural miniaturization of the Exotoxin A of the Pseudomonas for immunotoxins development
Exotoxin A of the Pseudomonas(PEA) is a potently cytotoxic factor for immunotoxins(ITs) designing, via targeting tumor specific antigens as well as inhibition of the protein synthesis. Nonetheless, the molecular size of ...
بررسی ویژگی های ساختاری، عملکردی و دامنه میزبانی آنزیم های مؤثر در تولید و تجمع لیپید در قارچ های روغنی
بیودیزل سوختی پاک، تجدیدپذیر، زیست‌تخریب‌پذیر، عاری از گوگرد و ترکیبات آروماتیک با منابع اولیه مشتق از چربی‌های حیوانی، گیاهی، جلبک‌ها، قارچ‌ها و باکتری‌ها می‌باشند. درمیان این منابع، قارچ‌های روغنی با توجه به قابلیت بالای ...
Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells
Background: Human FIX (hFIX) gene transfer into hepatocytes has provided a novel approach for treatment of hemophilia B. To obtain an improved expression of hFIX, the functional hFIX-expressing plasmids with appropriate ...
Evidences of the present of the promoter like elements into the non-coding regions of the human coagulation factor VIII gene
Accurate prediction of the Cis-regulatory elements encoded within DNA sequences
throughout the genomes and in different regions of a gene is a crucial step towards
understanding the regulatory mechanism of ...
Designing a genetics construct based on α-sarcin application for targeting colon cancer via in-silico evaluation
α-sarcin, a fungal ribotoxin, with the appropriate propertise in the size, thermostability, immunogencity, resistance to the proteases as well as cell death induction via ribosome inactivation, is a suitable candidate for ...
سنجش بیان مجازی آنتی‌ژن‌های اختصاصی سطح سلول‌های سرطانی پستان با اهداف دوگانه تشخیصی و درمانی
سرطان پستان که از مشکلات عمده بهداشت عمومی در جهان می‌باشد، رایج‌ترین سرطان در بین زنان و علت اصلی مرگ و میر ناشی از این نوع از بیماری در این قشر از جامعه است. لذا راهکارهای گسترده‌ای در جهت پیش آگاهی، تشخیص و درمان آن ...
An in-silico investigation into the bacterial exotoxins affecting cell death for designing a new generation of anti-cancer drugs
Statistical information about the incidence of cancer malignancies, reminded a high degree of
importance in providing innovative approaches for diagnosis, prevention and treatment of
these type of disease. ...
An Investigation On The Mesothelin Characteristics For Immunotoxin Development
Cell surface antigens are critical markers for diagnostic and healing of many diseases such as
cancer. In this regard, mesothelin as specixc antigen, with low expression on the normal cells and
over-expression ...
An in-silico expression assay of the MAGE family in malignances
Structural analysis and expression evaluation of the cell surface specific antigens of malignances could be providing new molecular approaches for diagnosis and target therapy of cancers. In this regard, MAGE family with ...